C4a/b Polyclonal Antibody

Name: C4a/b Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75542
Price: 225 USD
Availability: InStock

E20-75542Cite ID: EN0055675Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight192771Da

Protein NameComplement C4-A/Complement C4-B

Human Gene Id720/721

Human Swiss Prot NoP0C0L4/P0C0L5

SpecificityC4a/b Polyclonal Antibody detects endogenous levels of C4a/b protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameC4A; CO4; CPAMD2; Complement C4-A; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; C4B; CO4; CPAMD3; Complement C4-B; Basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3

Observed Band(KD)180

Functiondisease:Defects in C4A are the cause of C4A deficiency [MIM:120810].,disease:The C4A6 allotype is totally deficient in hemolytic activity.,function:C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.,function:Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.,miscellaneous:C4A allotypes react more rapidly with the amino group of peptide antigens

Subcellular Locationextracellular region,extracellular space,plasma membrane,cell junction,axon,dendrite,neuronal cell body,synapse,extracellular exosome,blood microparticle,

ExpressionBrain,Liver,Milk,Plasma,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human C4A/C4B. AA range:721-770

Gene NameC4A/C4B

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Backgroundcomplement C4A (Rodgers blood group)(C4A) Homo sapiens This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75542-Conjugate. Price: $485 / Size: 100μl.

E20-75542-FITC$485 / 100μlE20-75542-Biotin$485 / 100μlE20-75542-HRP$485 / 100μlE20-75542-AP$485 / 100μlE20-75542-AF350$485 / 100μlE20-75542-AF405M$485 / 100μlE20-75542-AF488$485 / 100μlE20-75542-AF514$485 / 100μlE20-75542-AF532$485 / 100μlE20-75542-AF555$485 / 100μlE20-75542-AF568$485 / 100μlE20-75542-AF405S$485 / 100μlE20-75542-AF405L$485 / 100μlE20-75542-AF546$485 / 100μlE20-75542-AF594$485 / 100μlE20-75542-AF610$485 / 100μlE20-75542-AF635$485 / 100μlE20-75542-AF647$485 / 100μlE20-75542-AF680$485 / 100μlE20-75542-AF700$485 / 100μlE20-75542-AF750$485 / 100μlE20-75542-AF790$485 / 100μlE20-75542-APC$485 / 100μlE20-75542-PE$485 / 100μlE20-75542-Cy3$485 / 100μlE20-75542-Cy5$485 / 100μlE20-75542-Cy5.5$485 / 100μlE20-75542-Cy7$485 / 100μlE20-75542-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.