World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
Cortactin Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight61636Da
Protein NameSrc substrate cortactin
Human Gene Id2017
Human Swiss Prot NoQ14247
Mouse Gene Id13043
Mouse Swiss Prot NoQ60598
SpecificityCortactin Polyclonal Antibody detects endogenous levels of Cortactin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1
Observed Band(KD)62
Functionfunction:May contribute to the organization of cell structure. The SH3 motif may function as a binding region to cytoskeleton. Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation.,online information:Cortactin entry,similarity:Contains 1 SH3 domain.,similarity:Contains 7 cortactin repeats.,subcellular location:Associated with membrane ruffles and lamellipodia.,subunit:Interacts with SHANK2 and SHANK3 via its SH2 domain. Also interacts with FGD1 (By similarity). Interacts with PLXDC2.,
Subcellular Locationruffle,podosome,cytoplasm,Golgi apparatus,cytoskeleton,actin filament,plasma membrane,clathrin-coated pit,cell-cell adherens junction,focal adhesion,cell cortex,voltage-gated potassium channel complex,lamellipodium,growth
ExpressionCoronary artery,Epithelium,Mammary gland,Placenta,Platelet,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human Cortactin.
Gene NameCTTN
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundcortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75539-Conjugate. Price: $485 / Size: 100μl.
E20-75539-FITC$485 / 100μlE20-75539-Biotin$485 / 100μlE20-75539-HRP$485 / 100μlE20-75539-AP$485 / 100μlE20-75539-AF350$485 / 100μlE20-75539-AF405M$485 / 100μlE20-75539-AF488$485 / 100μlE20-75539-AF514$485 / 100μlE20-75539-AF532$485 / 100μlE20-75539-AF555$485 / 100μlE20-75539-AF568$485 / 100μlE20-75539-AF405S$485 / 100μlE20-75539-AF405L$485 / 100μlE20-75539-AF546$485 / 100μlE20-75539-AF594$485 / 100μlE20-75539-AF610$485 / 100μlE20-75539-AF635$485 / 100μlE20-75539-AF647$485 / 100μlE20-75539-AF680$485 / 100μlE20-75539-AF700$485 / 100μlE20-75539-AF750$485 / 100μlE20-75539-AF790$485 / 100μlE20-75539-APC$485 / 100μlE20-75539-PE$485 / 100μlE20-75539-Cy3$485 / 100μlE20-75539-Cy5$485 / 100μlE20-75539-Cy5.5$485 / 100μlE20-75539-Cy7$485 / 100μlE20-75539-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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