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Cell Signal Transduction Research Antibodies
AR Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight98989Da
Protein NameAndrogen receptor
Human Gene Id367
Human Swiss Prot NoP10275
Mouse Gene Id11835
Mouse Swiss Prot NoP19091
Rat Gene Id24208
Rat Swiss Prot NoP15207
SpecificityAR Polyclonal Antibody detects endogenous levels of AR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameAR; DHTR; NR3C4; Androgen receptor; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4
Observed Band(KD)99
Functiondisease:Defects in AR are the cause of androgen insensitivity syndrome (AIS) [MIM:300068]; previously known as testicular feminization syndrome (TFM). AIS is an X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype.,disease:Defects in AR are the cause of androgen insensitivity syndrome partial (PAIS) [MIM:312300]; also known as Reifenstein syndrome. PAIS is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations.,disease:Defects in AR are the cause of spinal and bulb
Subcellular Locationnuclear chromatin,nucleus,nucleoplasm,cytoplasm,cytosol,plasma membrane,integral component of membrane,protein complex,
ExpressionBlood,Brain,Mammary carcinoma,Prostate,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human AR.
Gene NameAR
DilutionIF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
Backgroundandrogen receptor(AR) Homo sapiens The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoform
Conjugated Antibody
This product is also available conjugated. Format: E20-75538-Conjugate. Price: $485 / Size: 100μl.
E20-75538-FITC$485 / 100μlE20-75538-Biotin$485 / 100μlE20-75538-HRP$485 / 100μlE20-75538-AP$485 / 100μlE20-75538-AF350$485 / 100μlE20-75538-AF405M$485 / 100μlE20-75538-AF488$485 / 100μlE20-75538-AF514$485 / 100μlE20-75538-AF532$485 / 100μlE20-75538-AF555$485 / 100μlE20-75538-AF568$485 / 100μlE20-75538-AF405S$485 / 100μlE20-75538-AF405L$485 / 100μlE20-75538-AF546$485 / 100μlE20-75538-AF594$485 / 100μlE20-75538-AF610$485 / 100μlE20-75538-AF635$485 / 100μlE20-75538-AF647$485 / 100μlE20-75538-AF680$485 / 100μlE20-75538-AF700$485 / 100μlE20-75538-AF750$485 / 100μlE20-75538-AF790$485 / 100μlE20-75538-APC$485 / 100μlE20-75538-PE$485 / 100μlE20-75538-Cy3$485 / 100μlE20-75538-Cy5$485 / 100μlE20-75538-Cy5.5$485 / 100μlE20-75538-Cy7$485 / 100μlE20-75538-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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