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Cell Signal Transduction Research Antibodies
RSAD2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight42170Da
Protein NameRadical S-adenosyl methionine domain-containing protein 2
Human Gene Id91543
Human Swiss Prot NoQ8WXG1
Mouse Gene Id58185
Mouse Swiss Prot NoQ8CBB9
Rat Gene Id65190
Rat Swiss Prot NoO70600
SpecificityRSAD2 Polyclonal Antibody detects endogenous levels of RSAD2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameRSAD2; CIG5; Radical S-adenosyl methionine domain-containing protein 2; Cytomegalovirus-induced gene 5 protein; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Observed Band(KD)42
Functioncofactor:Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,function:Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.,induction:By interferon type I, type II and LPS. Little or no induction by interferon gamma is observed in monocytic cell lines. Induced by infection with human cytomegalovirus (HMCV), hepatitis C virus, yell
Subcellular Locationmitochondrion,mitochondrial outer membrane,mitochondrial inner membrane,endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,lipid particle,
ExpressionForeskin fibroblast,Macrophage,Prostate,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human RSAD2. AA range:21-70
Gene NameRSAD2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcofactor:Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.,function:Involved in antiviral defense. May impair virus budding by disrupting lipid rafts at the plasma membrane, a feature which is essential for the budding process of many viruses. Acts through binding with and inactivating FPPS, an enzyme involved in synthesis of cholesterol, farnesylated and geranylated proteins, ubiquinones dolichol and heme. Plays a major role in the cell antiviral state induced by type I and type II interferon. Displays antiviral effect against HIV-1 virus, hepatitis C virus, human cytomegalovirus, and aphaviruses, but not vesiculovirus.,induction:By interferon type I, type II and LPS. Little or no induction by interferon gamma is observed in monocytic cell lines. Induced by infection with human cytomegalovirus (HMCV), hepatitis C virus, yellow fever virus and Sendai virus, presumably through type I interferon pathway.,miscellaneous:Up-regulated in atherosclerosis. Latent viruses like HCMV may be involved in atherogenesis by initiating local inflammation. This may induce up-regulation of antiviral gene RSAD2, which modulates lipids synthesis, and thus could play a role in abnormal lipid accumulation leading to atherosclerosis.,similarity:Belongs to the RSAD2 family.,subcellular location:Probably associates with the cytosolic side of the endoplasmic reticulum. Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28.,subunit:Interacts with FPPS.,
Conjugated Antibody
This product is also available conjugated. Format: E20-75534-Conjugate. Price: $485 / Size: 100μl.
E20-75534-FITC$485 / 100μlE20-75534-Biotin$485 / 100μlE20-75534-HRP$485 / 100μlE20-75534-AP$485 / 100μlE20-75534-AF350$485 / 100μlE20-75534-AF405M$485 / 100μlE20-75534-AF488$485 / 100μlE20-75534-AF514$485 / 100μlE20-75534-AF532$485 / 100μlE20-75534-AF555$485 / 100μlE20-75534-AF568$485 / 100μlE20-75534-AF405S$485 / 100μlE20-75534-AF405L$485 / 100μlE20-75534-AF546$485 / 100μlE20-75534-AF594$485 / 100μlE20-75534-AF610$485 / 100μlE20-75534-AF635$485 / 100μlE20-75534-AF647$485 / 100μlE20-75534-AF680$485 / 100μlE20-75534-AF700$485 / 100μlE20-75534-AF750$485 / 100μlE20-75534-AF790$485 / 100μlE20-75534-APC$485 / 100μlE20-75534-PE$485 / 100μlE20-75534-Cy3$485 / 100μlE20-75534-Cy5$485 / 100μlE20-75534-Cy5.5$485 / 100μlE20-75534-Cy7$485 / 100μlE20-75534-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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