Neuregulin-1 Polyclonal Antibody

Name: Neuregulin-1 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75530
Price: 225 USD
Availability: InStock

E20-75530Cite ID: EN0055663Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight70392Da

Protein NamePro-neuregulin-1, membrane-bound isoform

Human Gene Id3084

Human Swiss Prot NoQ02297

Rat Gene Id112400

Rat Swiss Prot NoP43322

SpecificityNeuregulin-1 Polyclonal Antibody detects endogenous levels of Neuregulin-1 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameNRG1; GGF; HGL; HRGA; NDF; SMDF; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1

Observed Band(KD)70

Functionalternative products:Additional isoforms seem to exist. Isoforms have been classified as type I NRGs (isoforms with an Ig domain and a glycosylation domain, isoforms 1-8), type II NRGs (isoforms with an Ig domain but no glycosylation domain, isoform 9) and type III NRGs (isoforms with a Cys-rich domain, isoform 10). All these isoforms perform distinct tissue-specific functions,developmental stage:Detectable at early embryonic ages.,disease:A rare chromosomal aberration involving NRG1 produces gamma-heregulin. Translocation t(8;11) with ODZ4. The translocation fuses the 5'-end of ODZ4 to NRG1 (isoform 8). The product of this translocation was first thought to be an alternatively spliced isoform. Gamma-heregulin is a soluble activating ligand for the ERBB2-ERBB3 receptor complex and acts as an autocrine growth factor in a specific breast cancer cell line (MDA-MB-175). Not detected in breas

Subcellular Locationextracellular region,extracellular space,nucleus,cytoplasm,integral component of plasma membrane,external side of plasma membrane,membrane,integral component of membrane,apical plasma membrane,dendrite,axolemma,neuromuscular junction,GO

ExpressionBrain,Brain hippocampus,Cerebellum,Kidney adenocarcinoma,Mammary cancer,Ovary,Pituitary,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human NRG1. AA range:201-250

Gene NameNRG1

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundneuregulin 1(NRG1) Homo sapiens The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75530-Conjugate. Price: $485 / Size: 100μl.

E20-75530-FITC$485 / 100μlE20-75530-Biotin$485 / 100μlE20-75530-HRP$485 / 100μlE20-75530-AP$485 / 100μlE20-75530-AF350$485 / 100μlE20-75530-AF405M$485 / 100μlE20-75530-AF488$485 / 100μlE20-75530-AF514$485 / 100μlE20-75530-AF532$485 / 100μlE20-75530-AF555$485 / 100μlE20-75530-AF568$485 / 100μlE20-75530-AF405S$485 / 100μlE20-75530-AF405L$485 / 100μlE20-75530-AF546$485 / 100μlE20-75530-AF594$485 / 100μlE20-75530-AF610$485 / 100μlE20-75530-AF635$485 / 100μlE20-75530-AF647$485 / 100μlE20-75530-AF680$485 / 100μlE20-75530-AF700$485 / 100μlE20-75530-AF750$485 / 100μlE20-75530-AF790$485 / 100μlE20-75530-APC$485 / 100μlE20-75530-PE$485 / 100μlE20-75530-Cy3$485 / 100μlE20-75530-Cy5$485 / 100μlE20-75530-Cy5.5$485 / 100μlE20-75530-Cy7$485 / 100μlE20-75530-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.