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Cell Signal Transduction Research Antibodies
FAS Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37732Da
Protein NameTumor necrosis factor receptor superfamily member 6
Human Gene Id355
Human Swiss Prot NoP25445
Mouse Swiss Prot NoP25446
SpecificityFAS Polyclonal Antibody detects endogenous levels of FAS protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFAS; APT1; FAS1; TNFRSF6; Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; CD95
Observed Band(KD)37
Functiondisease:Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.,domain:Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.,function:Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vit
Subcellular Locationnucleus,cytoplasm,cytosol,plasma membrane,integral component of plasma membrane,external side of plasma membrane,cell surface,membrane,integral component of membrane,death-inducing signaling complex,CD95 death-inducing signaling co
ExpressionBlood,Brain,Liver,Peripheral blood lymphocyte,Urinary bladder,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human FAS. AA range:51-100
Gene NameFAS
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundFas cell surface death receptor(FAS) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, s
Conjugated Antibody
This product is also available conjugated. Format: E20-75526-Conjugate. Price: $485 / Size: 100μl.
E20-75526-FITC$485 / 100μlE20-75526-Biotin$485 / 100μlE20-75526-HRP$485 / 100μlE20-75526-AP$485 / 100μlE20-75526-AF350$485 / 100μlE20-75526-AF405M$485 / 100μlE20-75526-AF488$485 / 100μlE20-75526-AF514$485 / 100μlE20-75526-AF532$485 / 100μlE20-75526-AF555$485 / 100μlE20-75526-AF568$485 / 100μlE20-75526-AF405S$485 / 100μlE20-75526-AF405L$485 / 100μlE20-75526-AF546$485 / 100μlE20-75526-AF594$485 / 100μlE20-75526-AF610$485 / 100μlE20-75526-AF635$485 / 100μlE20-75526-AF647$485 / 100μlE20-75526-AF680$485 / 100μlE20-75526-AF700$485 / 100μlE20-75526-AF750$485 / 100μlE20-75526-AF790$485 / 100μlE20-75526-APC$485 / 100μlE20-75526-PE$485 / 100μlE20-75526-Cy3$485 / 100μlE20-75526-Cy5$485 / 100μlE20-75526-Cy5.5$485 / 100μlE20-75526-Cy7$485 / 100μlE20-75526-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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