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Cell Signal Transduction Research Antibodies
Netrin-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight67734Da
Protein NameNetrin-1
Human Gene Id9423
Human Swiss Prot NoO95631
Mouse Gene Id18208
Mouse Swiss Prot NoO09118
Rat Gene Id114523
Rat Swiss Prot NoQ924Z9
SpecificityNetrin-1 Polyclonal Antibody detects endogenous levels of Netrin-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNTN1; NTN1L; Netrin-1; Epididymis tissue protein Li 131P
Observed Band(KD)66
Functiondisease:Defects in NTN1 are associated with some forms of neuroblastomas.,function:Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis.,similarity:Contains 1 laminin N-terminal domain.,similarity:Contains 1 NTR domain.,similarity:Contains 3 laminin EGF-like domains.,subunit:Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and probably UNC5D.,tissue specificity:Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas.,
Subcellular Locationextracellular region,basement membrane,cytoplasm,
ExpressionBrain stem,Liver,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human NTN1. AA range:551-600
Gene NameNTN1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundnetrin 1(NTN1) Homo sapiens Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75522-Conjugate. Price: $485 / Size: 100μl.
E20-75522-FITC$485 / 100μlE20-75522-Biotin$485 / 100μlE20-75522-HRP$485 / 100μlE20-75522-AP$485 / 100μlE20-75522-AF350$485 / 100μlE20-75522-AF405M$485 / 100μlE20-75522-AF488$485 / 100μlE20-75522-AF514$485 / 100μlE20-75522-AF532$485 / 100μlE20-75522-AF555$485 / 100μlE20-75522-AF568$485 / 100μlE20-75522-AF405S$485 / 100μlE20-75522-AF405L$485 / 100μlE20-75522-AF546$485 / 100μlE20-75522-AF594$485 / 100μlE20-75522-AF610$485 / 100μlE20-75522-AF635$485 / 100μlE20-75522-AF647$485 / 100μlE20-75522-AF680$485 / 100μlE20-75522-AF700$485 / 100μlE20-75522-AF750$485 / 100μlE20-75522-AF790$485 / 100μlE20-75522-APC$485 / 100μlE20-75522-PE$485 / 100μlE20-75522-Cy3$485 / 100μlE20-75522-Cy5$485 / 100μlE20-75522-Cy5.5$485 / 100μlE20-75522-Cy7$485 / 100μlE20-75522-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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