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Cell Signal Transduction Research Antibodies
IGFBP3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight31674Da
Protein NameInsulin-like growth factor-binding protein 3
Human Gene Id3486
Human Swiss Prot NoP17936
Mouse Swiss Prot NoP47878
Rat Gene Id24484
Rat Swiss Prot NoP15473
SpecificityIGFBP3 Polyclonal Antibody detects endogenous levels of IGFBP3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIGFBP3; IBP3; Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3
Observed Band(KD)30
Functiondevelopmental stage:IGFBP3 levels are higher during extrauterine life and peak during puberty.,domain:The thyroglobulin type-1 domain mediates interaction with HN.,function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.,induction:IGFBP3 levels increase in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters.,online information:The Singapore human mutation and polymorphism database,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 k
Subcellular Locationextracellular region,extracellular space,nucleus,insulin-like growth factor binding protein complex,insulin-like growth factor ternary complex,extracellular exosome,
ExpressionCerebrospinal fluid,Kidney,Liver,Ovary,Plasma,Skin,Spleen,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IGFBP3. AA range:211-260
Gene NameIGFBP3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundinsulin like growth factor binding protein 3(IGFBP3) Homo sapiens This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75518-Conjugate. Price: $485 / Size: 100μl.
E20-75518-FITC$485 / 100μlE20-75518-Biotin$485 / 100μlE20-75518-HRP$485 / 100μlE20-75518-AP$485 / 100μlE20-75518-AF350$485 / 100μlE20-75518-AF405M$485 / 100μlE20-75518-AF488$485 / 100μlE20-75518-AF514$485 / 100μlE20-75518-AF532$485 / 100μlE20-75518-AF555$485 / 100μlE20-75518-AF568$485 / 100μlE20-75518-AF405S$485 / 100μlE20-75518-AF405L$485 / 100μlE20-75518-AF546$485 / 100μlE20-75518-AF594$485 / 100μlE20-75518-AF610$485 / 100μlE20-75518-AF635$485 / 100μlE20-75518-AF647$485 / 100μlE20-75518-AF680$485 / 100μlE20-75518-AF700$485 / 100μlE20-75518-AF750$485 / 100μlE20-75518-AF790$485 / 100μlE20-75518-APC$485 / 100μlE20-75518-PE$485 / 100μlE20-75518-Cy3$485 / 100μlE20-75518-Cy5$485 / 100μlE20-75518-Cy5.5$485 / 100μlE20-75518-Cy7$485 / 100μlE20-75518-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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