Product Information
Molecular Weight69069Da
Protein NameMyelin-associated glycoprotein
Human Gene Id4099
Human Swiss Prot NoP20916
Mouse Gene Id17136
Mouse Swiss Prot NoP20917
Rat Gene Id29409
Rat Swiss Prot NoP07722
SpecificityMAG Polyclonal Antibody detects endogenous levels of MAG protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMAG; GMA; Myelin-associated glycoprotein; Siglec-4a
Observed Band(KD)70
Functionfunction:Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid.,online information:Siglec-4,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds to RTN4R.,
Subcellular Locationcytoplasm,plasma membrane,integral component of membrane,paranode region of axon,myelin sheath adaxonal region,Schmidt-Lanterman incisure,mesaxon,
ExpressionBrain,Cerebellum,White Matter pool- 5 brain tissues- femoral artery,
Backgroundmyelin associated glycoprotein(MAG) Homo sapiens The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010],