Product Information
Molecular Weight26416Da
Protein NameFms-related tyrosine kinase 3 ligand
Human Gene Id2323
Human Swiss Prot NoP49771
Mouse Swiss Prot NoP49772
SpecificityFlt3-L Polyclonal Antibody detects endogenous levels of Flt3-L protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFLT3LG; Fms-related tyrosine kinase 3 ligand; Flt3 ligand; Flt3L; SL cytokine
Observed Band(KD)26
Functionfunction:Stimulates the proliferation of early hematopoietic cells. Synergizes well with a number of other colony stimulating factors and interleukins.,subunit:Homodimer (isoform 2).,
Subcellular Locationextracellular region,extracellular space,membrane,integral component of membrane,intrinsic component of external side of plasma membrane,
ExpressionBrain,Spleen,
Backgroundfms related tyrosine kinase 3 ligand(FLT3LG) Homo sapiens Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011],