World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
CD85c Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight(Da):32509
Protein NameTumor necrosis factor ligand superfamily member 10
Human Gene Id8743
Human Swiss Prot NoP50591
Mouse Swiss Prot NoP50592
SpecificityTRAIL Polyclonal Antibody detects endogenous levels of TRAIL protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNFSF10; APO2L; TRAIL; Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD253
Observed Band(KD)33
Functioncofactor:Binds 1 zinc ion per trimer.,function:Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Widespread; most predominant in spleen, lung and prostate.,
Subcellular Locationextracellular region,extracellular space,integral component of plasma membrane,integral component of membrane,extracellular exosome,
ExpressionLymph,Placenta,Small intestine,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF10. AA range:31-80
Gene NameTNFSF10
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundtumor necrosis factor superfamily member 10(TNFSF10) Homo sapiens The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provi
Conjugated Antibody
This product is also available conjugated. Format: E20-75510-Conjugate. Price: $485 / Size: 100μl.
E20-75510-FITC$485 / 100μlE20-75510-Biotin$485 / 100μlE20-75510-HRP$485 / 100μlE20-75510-AP$485 / 100μlE20-75510-AF350$485 / 100μlE20-75510-AF405M$485 / 100μlE20-75510-AF488$485 / 100μlE20-75510-AF514$485 / 100μlE20-75510-AF532$485 / 100μlE20-75510-AF555$485 / 100μlE20-75510-AF568$485 / 100μlE20-75510-AF405S$485 / 100μlE20-75510-AF405L$485 / 100μlE20-75510-AF546$485 / 100μlE20-75510-AF594$485 / 100μlE20-75510-AF610$485 / 100μlE20-75510-AF635$485 / 100μlE20-75510-AF647$485 / 100μlE20-75510-AF680$485 / 100μlE20-75510-AF700$485 / 100μlE20-75510-AF750$485 / 100μlE20-75510-AF790$485 / 100μlE20-75510-APC$485 / 100μlE20-75510-PE$485 / 100μlE20-75510-Cy3$485 / 100μlE20-75510-Cy5$485 / 100μlE20-75510-Cy5.5$485 / 100μlE20-75510-Cy7$485 / 100μlE20-75510-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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