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Cell Signal Transduction Research Antibodies
SREBP-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight121675Da
Protein NameSterol regulatory element-binding protein 1
Human Gene Id6720
Human Swiss Prot NoP36956
Mouse Gene Id20787
Mouse Swiss Prot NoQ9WTN3
Rat Gene Id78968
Rat Swiss Prot NoP56720
SpecificitySREBP-1 Polyclonal Antibody detects endogenous levels of SREBP-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSREBF1; BHLHD1; SREBP1; Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1
Observed Band(KD)120
Functionalternative products:Additional isoforms seem to exist,function:Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3').,online information:Sterol regulatory element-binding protein entry,PTM:At low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor fr
Subcellular LocationGolgi membrane,nucleus,nuclear envelope,nucleoplasm,cytoplasm,endoplasmic reticulum,endoplasmic reticulum membrane,cytosol,ER to Golgi transport vesicle membrane,integral component of membrane,protei
ExpressionBrain,Cervix carcinoma,Epithelium,Fetal bra
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human SREBP-1.
Gene NameSREBF1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsterol regulatory element binding transcription factor 1(SREBF1) Homo sapiens This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75508-Conjugate. Price: $485 / Size: 100μl.
E20-75508-FITC$485 / 100μlE20-75508-Biotin$485 / 100μlE20-75508-HRP$485 / 100μlE20-75508-AP$485 / 100μlE20-75508-AF350$485 / 100μlE20-75508-AF405M$485 / 100μlE20-75508-AF488$485 / 100μlE20-75508-AF514$485 / 100μlE20-75508-AF532$485 / 100μlE20-75508-AF555$485 / 100μlE20-75508-AF568$485 / 100μlE20-75508-AF405S$485 / 100μlE20-75508-AF405L$485 / 100μlE20-75508-AF546$485 / 100μlE20-75508-AF594$485 / 100μlE20-75508-AF610$485 / 100μlE20-75508-AF635$485 / 100μlE20-75508-AF647$485 / 100μlE20-75508-AF680$485 / 100μlE20-75508-AF700$485 / 100μlE20-75508-AF750$485 / 100μlE20-75508-AF790$485 / 100μlE20-75508-APC$485 / 100μlE20-75508-PE$485 / 100μlE20-75508-Cy3$485 / 100μlE20-75508-Cy5$485 / 100μlE20-75508-Cy5.5$485 / 100μlE20-75508-Cy7$485 / 100μlE20-75508-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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