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Cell Signal Transduction Research Antibodies
NCoA-3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight155293Da
Protein NameNuclear receptor coactivator 3
Human Gene Id8202
Human Swiss Prot NoQ9Y6Q9
Mouse Swiss Prot NoO09000
Rat Swiss Prot NoQ9EPU2
SpecificityNCoA-3 Polyclonal Antibody detects endogenous levels of NCoA-3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNCOA3; AIB1; BHLHE42; RAC3; TRAM1; Nuclear receptor coactivator 3; NCoA-3; ACTR; Amplified in breast cancer 1 protein; AIB-1; CBP-interacting protein; pCIP; Class E basic helix-loop-helix protein 42; bHLHe42; Receptor-associated coactivator 3; RAC-3; Steroid receptor coactivator protein 3; SRC-3; Thyroid hormone receptor activator molecule 1; TRAM-1
Observed Band(KD)160
Functionalternative products:Additional isoforms seem to exist,catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone.,domain:Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).,enzyme regulation:Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors.,function:Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubuni
Subcellular Locationnuclear chromatin,nucleus,nucleoplasm,cytoplasm,extracellular exosome,
ExpressionAorta endothelial cell,Brain,Epithelium,Leukemia,Lung,Lymph,PCR rescued clo
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human NCoA-3.
Gene NameNCOA3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundnuclear receptor coactivator 3(NCOA3) Homo sapiens The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75507-Conjugate. Price: $485 / Size: 100μl.
E20-75507-FITC$485 / 100μlE20-75507-Biotin$485 / 100μlE20-75507-HRP$485 / 100μlE20-75507-AP$485 / 100μlE20-75507-AF350$485 / 100μlE20-75507-AF405M$485 / 100μlE20-75507-AF488$485 / 100μlE20-75507-AF514$485 / 100μlE20-75507-AF532$485 / 100μlE20-75507-AF555$485 / 100μlE20-75507-AF568$485 / 100μlE20-75507-AF405S$485 / 100μlE20-75507-AF405L$485 / 100μlE20-75507-AF546$485 / 100μlE20-75507-AF594$485 / 100μlE20-75507-AF610$485 / 100μlE20-75507-AF635$485 / 100μlE20-75507-AF647$485 / 100μlE20-75507-AF680$485 / 100μlE20-75507-AF700$485 / 100μlE20-75507-AF750$485 / 100μlE20-75507-AF790$485 / 100μlE20-75507-APC$485 / 100μlE20-75507-PE$485 / 100μlE20-75507-Cy3$485 / 100μlE20-75507-Cy5$485 / 100μlE20-75507-Cy5.5$485 / 100μlE20-75507-Cy7$485 / 100μlE20-75507-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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