Histone H2B Polyclonal Antibody

Name: Histone H2B Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75501
Price: 225 USD
Availability: InStock

E20-75501Cite ID: EN0055634Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight13906/13936/13892/13890/13952/13989/13922/13920/13944Da

Protein NameHistone H2B type 1-C/E/F/G/I/Histone H2B type 1-D/Histone H2B type 1-H/Histone H2B type 1-K/Histone H2B type 1-L/Histone H2B type 1-M/Histone H2B type 1-N/Histone H2B type 2-F/Histone H2B type F-S

Human Gene Id3017/8339/8343/8344/8346/8347/3017/8345/85236/8340/8342/8341/440689

Human Swiss Prot NoP33778/P62807/P58876/Q93079/P06899/O60814/Q99880/Q99879/Q99877/P23527

Mouse Gene Id319178/319179/319182

SpecificityHistone H2B Polyclonal Antibody detects endogenous levels of Histone H2B protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameHIST1H2BB; H2BFF; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f; HIST1H2BC; H2BFL; HIST1H2BE; H2BFH; HIST1H2BF; H2BFG; HIST1H2BG; H2BFA; HIST1H2BI; H2BFK; Histone H2B type 1-C/E/F/G/I; Histone H2B.1 A; Histone H2B.a; H2B/a; Histone H2B.g; H2B/g; Histone H2B.h; H2B/h; Histone H2B.k; H2B/k; Histone H2B.l; H2B/l; HIST1H2BD; H2BFB; HIRIP2; Histone H2B type 1-D; HIRA-interacting protein 2; Histone H2B.1 B; Histone H2B.b; H2B/b; HIST1H2BH; H2BFJ; Histone H2B type 1-H; Histone H2B.j; H2B/j; HIST1H2BJ; H2BFR; Histone H2B type 1-J; Histone H2B.1; Histone H2B.r; H2B/r; HIST1H2BK; H2BFT; HIRIP1; Histone H2B type 1-K; H2B K; HIRA-interacting protein 1; HIST1H2BL; H2BFC; Histone H2B type 1-L; Histone H2B.c; H2B/c; HIST1H2BM; H2BFE; Histone H2B type 1-M; Histone H2B.e; H2B/e; HIST1H2BN; H2BFD; Histone H2B type 1-N; Histone H2B.d; H2B/d; HIST1H2BO; H2BFH; H2BFN; Histone H2B type 1-O; Histone H2B.2; Histone H2B.n; H2B/n

Observed Band(KD)15

Functionfunction:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Monoubiquitination of Lys-121 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.,PTM:Phosphorylated on Ser-15 by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DN

Subcellular Locationnuclear chromosome, telomeric region,nucleosome,nuclear nucleosome,nucleus,nucleoplasm,cytoplasm,

ExpressionEpithelium,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from the Internal region of human Histone H2B.

Gene NameHIST1H2BC/HIST1H2BE/HIST1H2BF/HIST1H2BG/HIST1H2BI/HIST1H2BD/HIST1H2BH/HIST1H2BK/HIST1H2BL/HIST1H2BM/HIST1H2BN/HIST2H2BF/H2BFS

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundhistone cluster 1 H2B family member b(HIST1H2BB) Homo sapiens Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75501-Conjugate. Price: $485 / Size: 100μl.

E20-75501-FITC$485 / 100μlE20-75501-Biotin$485 / 100μlE20-75501-HRP$485 / 100μlE20-75501-AP$485 / 100μlE20-75501-AF350$485 / 100μlE20-75501-AF405M$485 / 100μlE20-75501-AF488$485 / 100μlE20-75501-AF514$485 / 100μlE20-75501-AF532$485 / 100μlE20-75501-AF555$485 / 100μlE20-75501-AF568$485 / 100μlE20-75501-AF405S$485 / 100μlE20-75501-AF405L$485 / 100μlE20-75501-AF546$485 / 100μlE20-75501-AF594$485 / 100μlE20-75501-AF610$485 / 100μlE20-75501-AF635$485 / 100μlE20-75501-AF647$485 / 100μlE20-75501-AF680$485 / 100μlE20-75501-AF700$485 / 100μlE20-75501-AF750$485 / 100μlE20-75501-AF790$485 / 100μlE20-75501-APC$485 / 100μlE20-75501-PE$485 / 100μlE20-75501-Cy3$485 / 100μlE20-75501-Cy5$485 / 100μlE20-75501-Cy5.5$485 / 100μlE20-75501-Cy7$485 / 100μlE20-75501-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.