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Cell Signal Transduction Research Antibodies
Histone H2A Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight14091Da
Protein NameHistone H2A type 1
Human Gene Id8329/8330/8332/8336/8969
Human Swiss Prot NoP0C0S8
Mouse Gene Id319164
Mouse Swiss Prot NoP22752
Rat Swiss Prot NoP02262
SpecificityHistone H2A Polyclonal Antibody detects endogenous levels of Histone H2A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHIST1H2AG; H2AFP; HIST1H2AI; H2AFC; HIST1H2AK; H2AFD; HIST1H2AL; H2AFI; HIST1H2AM; H2AFN; Histone H2A type 1; H2A.1; Histone H2A/p
Observed Band(KD)15
Functionfunction:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,mass spectrometry:Monoisotopic with N-acetylserine PubMed:16457589,PTM:Deiminated on Arg-4 in granulocytes upon calcium entry.,PTM:Monoubiquitination of Lys-120 by RING1 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosom
Subcellular Locationnucleosome,nuclear chromatin,nucleus,extracellular exosome,
ExpressionBone,Brain,Colon,Eye,Lymph,PCR rescued clones,Placenta,Sple
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human Histone H2A.
Gene NameHIST1H2AG/HIST1H2AI/HIST1H2AK/HIST1H2AL/HIST1H2AM
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundhistone cluster 1 H2A family member i(HIST1H2AI) Homo sapiens Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75500-Conjugate. Price: $485 / Size: 100μl.
E20-75500-FITC$485 / 100μlE20-75500-Biotin$485 / 100μlE20-75500-HRP$485 / 100μlE20-75500-AP$485 / 100μlE20-75500-AF350$485 / 100μlE20-75500-AF405M$485 / 100μlE20-75500-AF488$485 / 100μlE20-75500-AF514$485 / 100μlE20-75500-AF532$485 / 100μlE20-75500-AF555$485 / 100μlE20-75500-AF568$485 / 100μlE20-75500-AF405S$485 / 100μlE20-75500-AF405L$485 / 100μlE20-75500-AF546$485 / 100μlE20-75500-AF594$485 / 100μlE20-75500-AF610$485 / 100μlE20-75500-AF635$485 / 100μlE20-75500-AF647$485 / 100μlE20-75500-AF680$485 / 100μlE20-75500-AF700$485 / 100μlE20-75500-AF750$485 / 100μlE20-75500-AF790$485 / 100μlE20-75500-APC$485 / 100μlE20-75500-PE$485 / 100μlE20-75500-Cy3$485 / 100μlE20-75500-Cy5$485 / 100μlE20-75500-Cy5.5$485 / 100μlE20-75500-Cy7$485 / 100μlE20-75500-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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