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Cell Signal Transduction Research Antibodies
HDAC1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight55103Da
Protein NameHistone deacetylase 1
Human Gene Id3065
Human Swiss Prot NoQ13547
Mouse Gene Id433759
Mouse Swiss Prot NoO09106
Rat Gene Id297893
Rat Swiss Prot NoQ4QQW4
SpecificityHDAC1 Polyclonal Antibody detects endogenous levels of HDAC1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHDAC1; RPD3L1; Histone deacetylase 1; HD1
Observed Band(KD)55
Functioncatalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.,PTM:Phosphorylation on Ser-421 and Ser-423 promotes enzymatic activity and interactions with NuRD and SIN3 complexes.,PTM:Sumoylated on Lys-444 and Lys-476; which promotes enzymatic activity. Desumoylated by SENP1.,similarity:Belongs to the histone deacetylase family. Type 1 subfamily.,subunit:Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates
Subcellular Locationhistone deacetylase complex,chromatin,nuclear chromatin,nucleus,nucleoplasm,cytoplasm,cytosol,Sin3 complex,NuRD complex,neuron projection,protein complex,perinuclear region of cytoplasm,
ExpressionEpithelium,Fetal brain,Fetal lung,Liver,Lung,T-cell,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the Internal region of human HDAC1.
Gene NameHDAC1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundhistone deacetylase 1(HDAC1) Homo sapiens Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75495-Conjugate. Price: $485 / Size: 100μl.
E20-75495-FITC$485 / 100μlE20-75495-Biotin$485 / 100μlE20-75495-HRP$485 / 100μlE20-75495-AP$485 / 100μlE20-75495-AF350$485 / 100μlE20-75495-AF405M$485 / 100μlE20-75495-AF488$485 / 100μlE20-75495-AF514$485 / 100μlE20-75495-AF532$485 / 100μlE20-75495-AF555$485 / 100μlE20-75495-AF568$485 / 100μlE20-75495-AF405S$485 / 100μlE20-75495-AF405L$485 / 100μlE20-75495-AF546$485 / 100μlE20-75495-AF594$485 / 100μlE20-75495-AF610$485 / 100μlE20-75495-AF635$485 / 100μlE20-75495-AF647$485 / 100μlE20-75495-AF680$485 / 100μlE20-75495-AF700$485 / 100μlE20-75495-AF750$485 / 100μlE20-75495-AF790$485 / 100μlE20-75495-APC$485 / 100μlE20-75495-PE$485 / 100μlE20-75495-Cy3$485 / 100μlE20-75495-Cy5$485 / 100μlE20-75495-Cy5.5$485 / 100μlE20-75495-Cy7$485 / 100μlE20-75495-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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