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Cell Signal Transduction Research Antibodies
UBA1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight117849Da
Protein NameUbiquitin-like modifier-activating enzyme 1
Human Gene Id7317
Human Swiss Prot NoP22314
Mouse Gene Id22201
Mouse Swiss Prot NoQ02053
Rat Gene Id314432
Rat Swiss Prot NoQ5U300
SpecificityUBA1 Polyclonal Antibody detects endogenous levels of UBA1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameUBA1; A1S9T; UBE1; Ubiquitin-like modifier-activating enzyme 1; Protein A1S9; Ubiquitin-activating enzyme E1
Observed Band(KD)118
Functiondisease:Defects in UBA1 are the cause of spinal muscular atrophy X-linked type 2 (SMAX2) [MIM:301830]; also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures.,function:Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP.,miscellaneous:There are two active sites within the E1 molecule, allowing it to accommodate two ubiquitin mo
Subcellular LocationCytoplasm . Mitochondrion . Nucleus .; [Isoform 1]: Nucleus .; [Isoform 2]: Cytoplasm .
ExpressionDetected in erythrocytes (at protein level). Ubiquitous.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human UBA1. AA range:91-140
Gene NameUBA1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundubiquitin like modifier activating enzyme 1(UBA1) Homo sapiens The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75493-Conjugate. Price: $485 / Size: 100μl.
E20-75493-FITC$485 / 100μlE20-75493-Biotin$485 / 100μlE20-75493-HRP$485 / 100μlE20-75493-AP$485 / 100μlE20-75493-AF350$485 / 100μlE20-75493-AF405M$485 / 100μlE20-75493-AF488$485 / 100μlE20-75493-AF514$485 / 100μlE20-75493-AF532$485 / 100μlE20-75493-AF555$485 / 100μlE20-75493-AF568$485 / 100μlE20-75493-AF405S$485 / 100μlE20-75493-AF405L$485 / 100μlE20-75493-AF546$485 / 100μlE20-75493-AF594$485 / 100μlE20-75493-AF610$485 / 100μlE20-75493-AF635$485 / 100μlE20-75493-AF647$485 / 100μlE20-75493-AF680$485 / 100μlE20-75493-AF700$485 / 100μlE20-75493-AF750$485 / 100μlE20-75493-AF790$485 / 100μlE20-75493-APC$485 / 100μlE20-75493-PE$485 / 100μlE20-75493-Cy3$485 / 100μlE20-75493-Cy5$485 / 100μlE20-75493-Cy5.5$485 / 100μlE20-75493-Cy7$485 / 100μlE20-75493-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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