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Cell Signal Transduction Research Antibodies
HLA-DQB1/2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight29991/30387Da
Protein NameHLA class II histocompatibility antigen DQ beta 1 chain/HLA class II histocompatibility antigen DQ beta 2 chain
Human Gene Id100507714
Human Swiss Prot NoP01920/P05538
SpecificityHLA-DQB1/2 Polyclonal Antibody detects endogenous levels of HLA-DQB1/2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHLA-DQB1; HLA-DQB; HLA class II histocompatibility antigen, DQ beta 1 chain; MHC class II antigen DQB1; HLA-DQB2; HLA-DXB; HLA class II histocompatibility antigen, DQ beta 2 chainHLA class II histocompatibility antigen, DX beta chain; MHC class II antigen DQB2
Observed Band(KD)30
Functioncaution:PubMed:6954511 have called the protein an HLA-DR antigen-like beta-chain.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,
Subcellular LocationCell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
ExpressionB-cell,Blood,Colon,Peripheral blood,Peripheral bloo
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQB1/HLA-DQB2. AA range:131-180
Gene NameHLA-DQB1/HLA-DQB2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmajor histocompatibility complex, class II, DQ beta 1(HLA-DQB1) Homo sapiens HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marro
Conjugated Antibody
This product is also available conjugated. Format: E20-75492-Conjugate. Price: $485 / Size: 100μl.
E20-75492-FITC$485 / 100μlE20-75492-Biotin$485 / 100μlE20-75492-HRP$485 / 100μlE20-75492-AP$485 / 100μlE20-75492-AF350$485 / 100μlE20-75492-AF405M$485 / 100μlE20-75492-AF488$485 / 100μlE20-75492-AF514$485 / 100μlE20-75492-AF532$485 / 100μlE20-75492-AF555$485 / 100μlE20-75492-AF568$485 / 100μlE20-75492-AF405S$485 / 100μlE20-75492-AF405L$485 / 100μlE20-75492-AF546$485 / 100μlE20-75492-AF594$485 / 100μlE20-75492-AF610$485 / 100μlE20-75492-AF635$485 / 100μlE20-75492-AF647$485 / 100μlE20-75492-AF680$485 / 100μlE20-75492-AF700$485 / 100μlE20-75492-AF750$485 / 100μlE20-75492-AF790$485 / 100μlE20-75492-APC$485 / 100μlE20-75492-PE$485 / 100μlE20-75492-Cy3$485 / 100μlE20-75492-Cy5$485 / 100μlE20-75492-Cy5.5$485 / 100μlE20-75492-Cy7$485 / 100μlE20-75492-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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