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Cell Signal Transduction Research Antibodies
CRF-RI Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight50719Da
Protein NameCorticotropin-releasing factor receptor 1
Human Gene Id1394
Human Swiss Prot NoP34998
Mouse Gene Id12921
Mouse Swiss Prot NoP35347
Rat Gene Id58959
Rat Swiss Prot NoP35353
SpecificityCRF-RI Polyclonal Antibody detects endogenous levels of CRF-RI protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCRHR1; CRFR; CRFR1; CRHR; Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1
Observed Band(KD)50
Functionfunction:This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.,PTM:C-terminal Ser or Thr residues may be phosphorylated.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.,
Subcellular LocationCell membrane; Multi-pass membrane protein. Endosome. Agonist-binding promotes endocytosis.
ExpressionPredominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CRHR1. AA range:71-120
Gene NameCRHR1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundcorticotropin releasing hormone receptor 1(CRHR1) Homo sapiens This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Aug 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75490-Conjugate. Price: $485 / Size: 100μl.
E20-75490-FITC$485 / 100μlE20-75490-Biotin$485 / 100μlE20-75490-HRP$485 / 100μlE20-75490-AP$485 / 100μlE20-75490-AF350$485 / 100μlE20-75490-AF405M$485 / 100μlE20-75490-AF488$485 / 100μlE20-75490-AF514$485 / 100μlE20-75490-AF532$485 / 100μlE20-75490-AF555$485 / 100μlE20-75490-AF568$485 / 100μlE20-75490-AF405S$485 / 100μlE20-75490-AF405L$485 / 100μlE20-75490-AF546$485 / 100μlE20-75490-AF594$485 / 100μlE20-75490-AF610$485 / 100μlE20-75490-AF635$485 / 100μlE20-75490-AF647$485 / 100μlE20-75490-AF680$485 / 100μlE20-75490-AF700$485 / 100μlE20-75490-AF750$485 / 100μlE20-75490-AF790$485 / 100μlE20-75490-APC$485 / 100μlE20-75490-PE$485 / 100μlE20-75490-Cy3$485 / 100μlE20-75490-Cy5$485 / 100μlE20-75490-Cy5.5$485 / 100μlE20-75490-Cy7$485 / 100μlE20-75490-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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