World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
STING/TMEM173 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight42193Da
Protein NameTransmembrane protein 173
Human Gene Id340061
Human Swiss Prot NoQ86WV6
Mouse Gene Id72512
Mouse Swiss Prot NoQ3TBT3
SpecificityTMEM173 Polyclonal Antibody detects endogenous levels of TMEM173 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTMEM173; ERIS; MITA; STING; Transmembrane protein 173; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Stimulator of interferon genes protein; hSTING
Observed Band(KD)42,23
Functionfunction:Acts as a facilitator of innate immune signaling. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.,PTM:Phosphorylated on tyrosine residues upon MHC-II aggregation.,subunit:Associates with the MHC-II complex (By similarity). Interacts with DDX58/RIG-I, MAVS/VISA and SSR2.,tissue specificity:Ubiquitously expressed.,
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum-Golgi intermediate compartment membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein . Mitochondrion outer membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . In response to double-stranded DNA stimulation, translocates from the endoplasmic reticulum through the endoplasmic reticulum-Golgi intermediate compartment and Golgi to post-Golgi vesicles, where the kinase TBK1 is recruited (PubMed:19433799, PubMed:30842659, PubMed:30842653, PubMed:29694889). Upon cGAMP-binding, translocates to the endoplasmic reticulum-Golgi interme
ExpressionUbiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Transmembrane protein 173 at AA range: 301-350
Gene NameTMEM173
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundtransmembrane protein 173(TMEM173) Homo sapiens This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75488-Conjugate. Price: $485 / Size: 100μl.
E20-75488-FITC$485 / 100μlE20-75488-Biotin$485 / 100μlE20-75488-HRP$485 / 100μlE20-75488-AP$485 / 100μlE20-75488-AF350$485 / 100μlE20-75488-AF405M$485 / 100μlE20-75488-AF488$485 / 100μlE20-75488-AF514$485 / 100μlE20-75488-AF532$485 / 100μlE20-75488-AF555$485 / 100μlE20-75488-AF568$485 / 100μlE20-75488-AF405S$485 / 100μlE20-75488-AF405L$485 / 100μlE20-75488-AF546$485 / 100μlE20-75488-AF594$485 / 100μlE20-75488-AF610$485 / 100μlE20-75488-AF635$485 / 100μlE20-75488-AF647$485 / 100μlE20-75488-AF680$485 / 100μlE20-75488-AF700$485 / 100μlE20-75488-AF750$485 / 100μlE20-75488-AF790$485 / 100μlE20-75488-APC$485 / 100μlE20-75488-PE$485 / 100μlE20-75488-Cy3$485 / 100μlE20-75488-Cy5$485 / 100μlE20-75488-Cy5.5$485 / 100μlE20-75488-Cy7$485 / 100μlE20-75488-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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