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Cell Signal Transduction Research Antibodies
IL-33 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight30759Da
Protein NameInterleukin-33
Human Gene Id90865
Human Swiss Prot NoO95760
Mouse Gene Id77125
Mouse Swiss Prot NoQ8BVZ5
Rat Gene Id361749
Rat Swiss Prot NoQ66H70
SpecificityIL-33 Polyclonal Antibody detects endogenous levels of IL-33 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL33; C9orf26; IL1F11; NFHEV; Interleukin-33; IL-33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV
Observed Band(KD)31
Functioncaution:Was originally (PubMed:12819012) thought to one of the key factors that controls the specialized post-capillary high endothelial venules (HEV) phenotype found in organized secondary lymphoid tissue and to be nuclear localized.,function:Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T helper type 2-associated cytokines.,PTM:Proteolytically converted to a mature form by CASP1.,similarity:Belongs to the IL-1 family. Highly divergent.,tissue specificity:Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.,
Subcellular LocationNucleus . Chromosome . Cytoplasm . Cytoplasmic vesicle, secretory vesicle . Secreted . Associates with heterochromatin and mitotic chromosomes (PubMed:17185418). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
ExpressionExpressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL33. AA range:121-170
Gene NameIL33
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundinterleukin 33(IL33) Homo sapiens The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75487-Conjugate. Price: $485 / Size: 100μl.
E20-75487-FITC$485 / 100μlE20-75487-Biotin$485 / 100μlE20-75487-HRP$485 / 100μlE20-75487-AP$485 / 100μlE20-75487-AF350$485 / 100μlE20-75487-AF405M$485 / 100μlE20-75487-AF488$485 / 100μlE20-75487-AF514$485 / 100μlE20-75487-AF532$485 / 100μlE20-75487-AF555$485 / 100μlE20-75487-AF568$485 / 100μlE20-75487-AF405S$485 / 100μlE20-75487-AF405L$485 / 100μlE20-75487-AF546$485 / 100μlE20-75487-AF594$485 / 100μlE20-75487-AF610$485 / 100μlE20-75487-AF635$485 / 100μlE20-75487-AF647$485 / 100μlE20-75487-AF680$485 / 100μlE20-75487-AF700$485 / 100μlE20-75487-AF750$485 / 100μlE20-75487-AF790$485 / 100μlE20-75487-APC$485 / 100μlE20-75487-PE$485 / 100μlE20-75487-Cy3$485 / 100μlE20-75487-Cy5$485 / 100μlE20-75487-Cy5.5$485 / 100μlE20-75487-Cy7$485 / 100μlE20-75487-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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