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Cell Signal Transduction Research Antibodies
CD316 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight65034Da
Protein NameImmunoglobulin superfamily member 8
Human Gene Id93185
Human Swiss Prot NoQ969P0
Mouse Gene Id140559
Mouse Swiss Prot NoQ8R366
SpecificityCD316 Polyclonal Antibody detects endogenous levels of CD316 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIGSF8; CD81P3; EWI2; KCT4; Immunoglobulin superfamily member 8; IgSF8; CD81 partner 3; Glu-Trp-Ile EWI motif-containing protein 2; EWI-2; Keratinocytes-associated transmembrane protein 4; KCT-4; LIR-D1; Prostaglandin regulatory-like protein; PGRL; CD316
Observed Band(KD)65
Functiondomain:The Ig-like C2-type domains 3 and 4 are required for interaction with CD81.,function:May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts directly with CD82, CD81/tetraspanin-28 and CD9/tetraspanin-29. Also interac
Subcellular LocationCell membrane ; Single-pass membrane protein.
ExpressionExpressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IGSF8. AA range:451-500
Gene NameIGSF8
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundimmunoglobulin superfamily member 8(IGSF8) Homo sapiens This gene encodes a member the EWI subfamily of the immunoglobulin protein superfamily. Members of this family contain a single transmembrane domain, an EWI (Glu-Trp-Ile)-motif and a variable number of immunoglobulin domains. This protein interacts with the tetraspanins CD81 and CD9 and may regulate their role in certain cellular functions including cell migration and viral infection. The encoded protein may also function as a tumor suppressor by inhibiting the proliferation of certain cancers. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75482-Conjugate. Price: $485 / Size: 100μl.
E20-75482-FITC$485 / 100μlE20-75482-Biotin$485 / 100μlE20-75482-HRP$485 / 100μlE20-75482-AP$485 / 100μlE20-75482-AF350$485 / 100μlE20-75482-AF405M$485 / 100μlE20-75482-AF488$485 / 100μlE20-75482-AF514$485 / 100μlE20-75482-AF532$485 / 100μlE20-75482-AF555$485 / 100μlE20-75482-AF568$485 / 100μlE20-75482-AF405S$485 / 100μlE20-75482-AF405L$485 / 100μlE20-75482-AF546$485 / 100μlE20-75482-AF594$485 / 100μlE20-75482-AF610$485 / 100μlE20-75482-AF635$485 / 100μlE20-75482-AF647$485 / 100μlE20-75482-AF680$485 / 100μlE20-75482-AF700$485 / 100μlE20-75482-AF750$485 / 100μlE20-75482-AF790$485 / 100μlE20-75482-APC$485 / 100μlE20-75482-PE$485 / 100μlE20-75482-Cy3$485 / 100μlE20-75482-Cy5$485 / 100μlE20-75482-Cy5.5$485 / 100μlE20-75482-Cy7$485 / 100μlE20-75482-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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