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Cell Signal Transduction Research Antibodies
JAM-A Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight32583Da
Protein NameJunctional adhesion molecule A
Human Gene Id50848
Human Swiss Prot NoQ9Y624
Mouse Gene Id16456
Mouse Swiss Prot NoO88792
Rat Gene Id116479
Rat Swiss Prot NoQ9JHY1
SpecificityJAM-A Polyclonal Antibody detects endogenous levels of JAM-A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameF11R; JAM1; JCAM; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; Platelet F11 receptor; Platelet adhesion molecule 1; PAM-1; CD321
Observed Band(KD)32
Functionfunction:Seems to plays a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus.,PTM:N-glycosylated.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,subcellular location:Localized at tight junctions of both epithelial and endothelial cells.,subunit:Interacts with the ninth PDZ domain of MPDZ. Interacts with the first PDZ domain of PARD3. The association between PARD3 and PARD6B probably disrupts this interactio
Subcellular LocationCell junction, tight junction . Cell membrane ; Single-pass type I membrane protein . Localized at tight junctions of both epithelial and endothelial cells. .
ExpressionExpressed in endothelium, epithelium and leukocytes (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human F11R. AA range:191-240
Gene NameF11R
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundF11 receptor(F11R) Homo sapiens Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75479-Conjugate. Price: $485 / Size: 100μl.
E20-75479-FITC$485 / 100μlE20-75479-Biotin$485 / 100μlE20-75479-HRP$485 / 100μlE20-75479-AP$485 / 100μlE20-75479-AF350$485 / 100μlE20-75479-AF405M$485 / 100μlE20-75479-AF488$485 / 100μlE20-75479-AF514$485 / 100μlE20-75479-AF532$485 / 100μlE20-75479-AF555$485 / 100μlE20-75479-AF568$485 / 100μlE20-75479-AF405S$485 / 100μlE20-75479-AF405L$485 / 100μlE20-75479-AF546$485 / 100μlE20-75479-AF594$485 / 100μlE20-75479-AF610$485 / 100μlE20-75479-AF635$485 / 100μlE20-75479-AF647$485 / 100μlE20-75479-AF680$485 / 100μlE20-75479-AF700$485 / 100μlE20-75479-AF750$485 / 100μlE20-75479-AF790$485 / 100μlE20-75479-APC$485 / 100μlE20-75479-PE$485 / 100μlE20-75479-Cy3$485 / 100μlE20-75479-Cy5$485 / 100μlE20-75479-Cy5.5$485 / 100μlE20-75479-Cy7$485 / 100μlE20-75479-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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