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Cell Signal Transduction Research Antibodies
DCL-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight26183Da
Protein NameCD302 antigen
Human Gene Id9936
Human Swiss Prot NoQ8IX05
Mouse Swiss Prot NoQ9DCG2
SpecificityDCL-1 Polyclonal Antibody detects endogenous levels of DCL-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD302; CLEC13A; DCL1; KIAA0022; CD302 antigen; C-type lectin BIMLEC; C-type lectin domain family 13 member A; DEC205-associated C-type lectin 1; Type I transmembrane C-type lectin receptor DCL-1; CD302
Observed Band(KD)26
Functionfunction:Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.,miscellaneous:Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.,online information:DEC-205,PTM:N-glycosylated.,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 10 C-type lectin domains.,tissue specificity:Expressed in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin's lymphoma cells called Hodgkin's and Reed-Sternberg (HRS) cells.,tissue specifici
Subcellular LocationMembrane ; Single-pass type I membrane protein . Cell projection, filopodium . Cytoplasm, cell cortex . Cell projection, microvillus . Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.
ExpressionExpressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD302. AA range:81-130
Gene NameCD302
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD302 molecule(CD302) Homo sapiens CD302 is a C-type lectin receptor involved in cell adhesion and migration, as well as endocytosis and phagocytosis (Kato et al., 2007 [PubMed 17947679]).[supplied by OMIM, Aug 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75473-Conjugate. Price: $485 / Size: 100μl.
E20-75473-FITC$485 / 100μlE20-75473-Biotin$485 / 100μlE20-75473-HRP$485 / 100μlE20-75473-AP$485 / 100μlE20-75473-AF350$485 / 100μlE20-75473-AF405M$485 / 100μlE20-75473-AF488$485 / 100μlE20-75473-AF514$485 / 100μlE20-75473-AF532$485 / 100μlE20-75473-AF555$485 / 100μlE20-75473-AF568$485 / 100μlE20-75473-AF405S$485 / 100μlE20-75473-AF405L$485 / 100μlE20-75473-AF546$485 / 100μlE20-75473-AF594$485 / 100μlE20-75473-AF610$485 / 100μlE20-75473-AF635$485 / 100μlE20-75473-AF647$485 / 100μlE20-75473-AF680$485 / 100μlE20-75473-AF700$485 / 100μlE20-75473-AF750$485 / 100μlE20-75473-AF790$485 / 100μlE20-75473-APC$485 / 100μlE20-75473-PE$485 / 100μlE20-75473-Cy3$485 / 100μlE20-75473-Cy5$485 / 100μlE20-75473-Cy5.5$485 / 100μlE20-75473-Cy7$485 / 100μlE20-75473-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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