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Cell Signal Transduction Research Antibodies
IL-18R Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight62304Da
Protein NameInterleukin-18 receptor 1
Human Gene Id8809
Human Swiss Prot NoQ13478
Mouse Swiss Prot NoQ61098
SpecificityIL-18R Polyclonal Antibody detects endogenous levels of IL-18R protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL18R1; IL1RRP; Interleukin-18 receptor 1; IL-18R-1; IL-18R1; CD218 antigen-like family member A; CDw218a; IL1 receptor-related protein; IL-1Rrp; IL1R-rp; CD218a
Observed Band(KD)63
Functionfunction:Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.,miscellaneous:Does not bind interleukin 1 alpha (IL-1A) or interleukin 1 beta (IL-1B).,similarity:Belongs to the interleukin-1 receptor family.,similarity:Contains 1 TIR domain.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin's disease cell lines.,
Subcellular LocationMembrane ; Single-pass type I membrane protein .
ExpressionHighly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL18R1. AA range:231-280
Gene NameIL18R1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundinterleukin 18 receptor 1(IL18R1) Homo sapiens The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-75472-Conjugate. Price: $485 / Size: 100μl.
E20-75472-FITC$485 / 100μlE20-75472-Biotin$485 / 100μlE20-75472-HRP$485 / 100μlE20-75472-AP$485 / 100μlE20-75472-AF350$485 / 100μlE20-75472-AF405M$485 / 100μlE20-75472-AF488$485 / 100μlE20-75472-AF514$485 / 100μlE20-75472-AF532$485 / 100μlE20-75472-AF555$485 / 100μlE20-75472-AF568$485 / 100μlE20-75472-AF405S$485 / 100μlE20-75472-AF405L$485 / 100μlE20-75472-AF546$485 / 100μlE20-75472-AF594$485 / 100μlE20-75472-AF610$485 / 100μlE20-75472-AF635$485 / 100μlE20-75472-AF647$485 / 100μlE20-75472-AF680$485 / 100μlE20-75472-AF700$485 / 100μlE20-75472-AF750$485 / 100μlE20-75472-AF790$485 / 100μlE20-75472-APC$485 / 100μlE20-75472-PE$485 / 100μlE20-75472-Cy3$485 / 100μlE20-75472-Cy5$485 / 100μlE20-75472-Cy5.5$485 / 100μlE20-75472-Cy7$485 / 100μlE20-75472-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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