World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
CD110 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight71245Da
Protein NameThrombopoietin receptor
Human Gene Id4352
Human Swiss Prot NoP40238
Mouse Gene Id17480
Mouse Swiss Prot NoQ08351
SpecificityCD110 Polyclonal Antibody detects endogenous levels of CD110 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMPL; TPOR; Thrombopoietin receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD110
Observed Band(KD)69,40
Functioncaution:It is uncertain whether Met-1 or Met-8 is the initiator.,disease:Defects in MPL are a cause of congenital amegakaryocytic thrombocytopenia (CAMT) [MIM:604498]. CAMT is a disease characterized by isolated thrombocytopenia and megakaryocytopenia with no physical anomalies.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.,similarity:Belongs to the type I cytokine receptor family. Type 1 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with ATXN2L.,tissue specificity:Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and
Subcellular LocationCell membrane ; Single-pass type I membrane protein. Golgi apparatus . Cell surface .
ExpressionExpressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Thrombopoietin receptor at AA range: 321-370
Gene NameMPL
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundMPL proto-oncogene, thrombopoietin receptor(MPL) Homo sapiens In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important
Conjugated Antibody
This product is also available conjugated. Format: E20-75469-Conjugate. Price: $485 / Size: 100μl.
E20-75469-FITC$485 / 100μlE20-75469-Biotin$485 / 100μlE20-75469-HRP$485 / 100μlE20-75469-AP$485 / 100μlE20-75469-AF350$485 / 100μlE20-75469-AF405M$485 / 100μlE20-75469-AF488$485 / 100μlE20-75469-AF514$485 / 100μlE20-75469-AF532$485 / 100μlE20-75469-AF555$485 / 100μlE20-75469-AF568$485 / 100μlE20-75469-AF405S$485 / 100μlE20-75469-AF405L$485 / 100μlE20-75469-AF546$485 / 100μlE20-75469-AF594$485 / 100μlE20-75469-AF610$485 / 100μlE20-75469-AF635$485 / 100μlE20-75469-AF647$485 / 100μlE20-75469-AF680$485 / 100μlE20-75469-AF700$485 / 100μlE20-75469-AF750$485 / 100μlE20-75469-AF790$485 / 100μlE20-75469-APC$485 / 100μlE20-75469-PE$485 / 100μlE20-75469-Cy3$485 / 100μlE20-75469-Cy5$485 / 100μlE20-75469-Cy5.5$485 / 100μlE20-75469-Cy7$485 / 100μlE20-75469-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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