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Cell Signal Transduction Research Antibodies
Integrin β4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight202151Da
Protein NameIntegrin beta-4
Human Gene Id3691
Human Swiss Prot NoP16144
Mouse Swiss Prot NoA2A863
Rat Gene Id25724
Rat Swiss Prot NoQ64632
SpecificityIntegrin β4 Polyclonal Antibody detects endogenous levels of Integrin β4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameITGB4; Integrin beta-4; GP150; CD104
Observed Band(KD)200
Functiondisease:Defects in ITGB4 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.,disease:Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. GABEB is a non-lethal, adult form of junctional epidermolysis bullosa characterized by life-long blistering of
Subcellular LocationCell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Colocalizes with DST at the leading edge of migrating keratinocytes.
ExpressionIntegrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ITGB4. AA range:641-690
Gene NameITGB4
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundintegrin subunit beta 4(ITGB4) Homo sapiens Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75468-Conjugate. Price: $485 / Size: 100μl.
E20-75468-FITC$485 / 100μlE20-75468-Biotin$485 / 100μlE20-75468-HRP$485 / 100μlE20-75468-AP$485 / 100μlE20-75468-AF350$485 / 100μlE20-75468-AF405M$485 / 100μlE20-75468-AF488$485 / 100μlE20-75468-AF514$485 / 100μlE20-75468-AF532$485 / 100μlE20-75468-AF555$485 / 100μlE20-75468-AF568$485 / 100μlE20-75468-AF405S$485 / 100μlE20-75468-AF405L$485 / 100μlE20-75468-AF546$485 / 100μlE20-75468-AF594$485 / 100μlE20-75468-AF610$485 / 100μlE20-75468-AF635$485 / 100μlE20-75468-AF647$485 / 100μlE20-75468-AF680$485 / 100μlE20-75468-AF700$485 / 100μlE20-75468-AF750$485 / 100μlE20-75468-AF790$485 / 100μlE20-75468-APC$485 / 100μlE20-75468-PE$485 / 100μlE20-75468-Cy3$485 / 100μlE20-75468-Cy5$485 / 100μlE20-75468-Cy5.5$485 / 100μlE20-75468-Cy7$485 / 100μlE20-75468-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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