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Cell Signal Transduction Research Antibodies
CD74 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight33516Da
Protein NameHLA class II histocompatibility antigen gamma chain
Human Gene Id972
Human Swiss Prot NoP04233
Mouse Swiss Prot NoP04441
SpecificityCD74 Polyclonal Antibody detects endogenous levels of CD74 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD74; DHLAG; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Ia antigen-associated invariant chain; Ii; p33; CD74
Observed Band(KD)33
Functionfunction:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Nonamer composed of three alpha/beta/gamma heterotrimers.,
Subcellular LocationCell membrane ; Single-pass type II membrane protein . Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome . Lysosome .
Expression[Isoform p41]: In B cells, represents 10% of total CD74 expression. ; [Isoform p33]: In B cells, represents 70% of total CD74 expression.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD74. AA range:161-210
Gene NameCD74
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundCD74 molecule(CD74) Homo sapiens The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75464-Conjugate. Price: $485 / Size: 100μl.
E20-75464-FITC$485 / 100μlE20-75464-Biotin$485 / 100μlE20-75464-HRP$485 / 100μlE20-75464-AP$485 / 100μlE20-75464-AF350$485 / 100μlE20-75464-AF405M$485 / 100μlE20-75464-AF488$485 / 100μlE20-75464-AF514$485 / 100μlE20-75464-AF532$485 / 100μlE20-75464-AF555$485 / 100μlE20-75464-AF568$485 / 100μlE20-75464-AF405S$485 / 100μlE20-75464-AF405L$485 / 100μlE20-75464-AF546$485 / 100μlE20-75464-AF594$485 / 100μlE20-75464-AF610$485 / 100μlE20-75464-AF635$485 / 100μlE20-75464-AF647$485 / 100μlE20-75464-AF680$485 / 100μlE20-75464-AF700$485 / 100μlE20-75464-AF750$485 / 100μlE20-75464-AF790$485 / 100μlE20-75464-APC$485 / 100μlE20-75464-PE$485 / 100μlE20-75464-Cy3$485 / 100μlE20-75464-Cy5$485 / 100μlE20-75464-Cy5.5$485 / 100μlE20-75464-Cy7$485 / 100μlE20-75464-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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