Integrin β2 Polyclonal Antibody

Name: Integrin β2 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75461
Price: 225 USD
Availability: InStock

E20-75461Cite ID: EN0055594Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight84782Da

Protein NameIntegrin beta-2

Human Gene Id3689

Human Swiss Prot NoP05107

Mouse Swiss Prot NoP11835

SpecificityIntegrin β2 Polyclonal Antibody detects endogenous levels of Integrin β2 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD18

Observed Band(KD)95

Functiondisease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S

Subcellular LocationCell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

ExpressionLeukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ITGB2. AA range:621-670

Gene NameITGB2

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Backgroundintegrin subunit beta 2(ITGB2) Homo sapiens This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75461-Conjugate. Price: $485 / Size: 100μl.

E20-75461-FITC$485 / 100μlE20-75461-Biotin$485 / 100μlE20-75461-HRP$485 / 100μlE20-75461-AP$485 / 100μlE20-75461-AF350$485 / 100μlE20-75461-AF405M$485 / 100μlE20-75461-AF488$485 / 100μlE20-75461-AF514$485 / 100μlE20-75461-AF532$485 / 100μlE20-75461-AF555$485 / 100μlE20-75461-AF568$485 / 100μlE20-75461-AF405S$485 / 100μlE20-75461-AF405L$485 / 100μlE20-75461-AF546$485 / 100μlE20-75461-AF594$485 / 100μlE20-75461-AF610$485 / 100μlE20-75461-AF635$485 / 100μlE20-75461-AF647$485 / 100μlE20-75461-AF680$485 / 100μlE20-75461-AF700$485 / 100μlE20-75461-AF750$485 / 100μlE20-75461-AF790$485 / 100μlE20-75461-APC$485 / 100μlE20-75461-PE$485 / 100μlE20-75461-Cy3$485 / 100μlE20-75461-Cy5$485 / 100μlE20-75461-Cy5.5$485 / 100μlE20-75461-Cy7$485 / 100μlE20-75461-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.