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Cell Signal Transduction Research Antibodies
Integrin αD Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight126886Da
Protein NameIntegrin alpha-D
Human Gene Id3681
Human Swiss Prot NoQ13349
Mouse Swiss Prot NoQ3V0T4
SpecificityIntegrin αD Polyclonal Antibody detects endogenous levels of Integrin αD protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameITGAD; Integrin alpha-D; ADB2; CD11 antigen-like family member D; Leukointegrin alpha D; CD11d
Observed Band(KD)127
Functiondomain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domain.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. Alpha-D associates with beta-2.,tissue specificity:Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.,
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionExpressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ITGAD. AA range:901-950
Gene NameITGAD
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundintegrin subunit alpha D(ITGAD) Homo sapiens This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75460-Conjugate. Price: $485 / Size: 100μl.
E20-75460-FITC$485 / 100μlE20-75460-Biotin$485 / 100μlE20-75460-HRP$485 / 100μlE20-75460-AP$485 / 100μlE20-75460-AF350$485 / 100μlE20-75460-AF405M$485 / 100μlE20-75460-AF488$485 / 100μlE20-75460-AF514$485 / 100μlE20-75460-AF532$485 / 100μlE20-75460-AF555$485 / 100μlE20-75460-AF568$485 / 100μlE20-75460-AF405S$485 / 100μlE20-75460-AF405L$485 / 100μlE20-75460-AF546$485 / 100μlE20-75460-AF594$485 / 100μlE20-75460-AF610$485 / 100μlE20-75460-AF635$485 / 100μlE20-75460-AF647$485 / 100μlE20-75460-AF680$485 / 100μlE20-75460-AF700$485 / 100μlE20-75460-AF750$485 / 100μlE20-75460-AF790$485 / 100μlE20-75460-APC$485 / 100μlE20-75460-PE$485 / 100μlE20-75460-Cy3$485 / 100μlE20-75460-Cy5$485 / 100μlE20-75460-Cy5.5$485 / 100μlE20-75460-Cy7$485 / 100μlE20-75460-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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