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Cell Signal Transduction Research Antibodies
PRX I Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight21890Da
Protein NamePeroxiredoxin-1
Human Gene Id5052
Human Swiss Prot NoQ06830
Mouse Gene Id18477
Mouse Swiss Prot NoP35700
Rat Gene Id117254
Rat Swiss Prot NoQ63716
SpecificityPRX I Polyclonal Antibody detects endogenous levels of PRX I protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePRDX1; PAGA; PAGB; TDPX2; Peroxiredoxin-1; Natural killer cell-enhancing factor A; NKEF-A; Proliferation-associated gene protein; PAG; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
Observed Band(KD)21
Functioncatalytic activity:2 R'-SH + ROOH = R'-S-S-R' + H(2)O + ROH.,function:Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).,induction:Constitutively expressed in most human cells; is induced to higher levels upon serum stimulation in untransformed and transformed cells.,miscellaneous:Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized.,miscellaneous:The active site is the redox-active Cys-52 oxidized to Cys-SOH.
Subcellular LocationCytoplasm . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
ExpressionBrain,Cajal-Retzius cell,Fetal brain cortex,Urinary bladder,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PRDX1. AA range:31-80
Gene NamePRDX1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundperoxiredoxin 1(PRDX1) Homo sapiens This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75455-Conjugate. Price: $485 / Size: 100μl.
E20-75455-FITC$485 / 100μlE20-75455-Biotin$485 / 100μlE20-75455-HRP$485 / 100μlE20-75455-AP$485 / 100μlE20-75455-AF350$485 / 100μlE20-75455-AF405M$485 / 100μlE20-75455-AF488$485 / 100μlE20-75455-AF514$485 / 100μlE20-75455-AF532$485 / 100μlE20-75455-AF555$485 / 100μlE20-75455-AF568$485 / 100μlE20-75455-AF405S$485 / 100μlE20-75455-AF405L$485 / 100μlE20-75455-AF546$485 / 100μlE20-75455-AF594$485 / 100μlE20-75455-AF610$485 / 100μlE20-75455-AF635$485 / 100μlE20-75455-AF647$485 / 100μlE20-75455-AF680$485 / 100μlE20-75455-AF700$485 / 100μlE20-75455-AF750$485 / 100μlE20-75455-AF790$485 / 100μlE20-75455-APC$485 / 100μlE20-75455-PE$485 / 100μlE20-75455-Cy3$485 / 100μlE20-75455-Cy5$485 / 100μlE20-75455-Cy5.5$485 / 100μlE20-75455-Cy7$485 / 100μlE20-75455-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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