World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
MCM6 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight90310Da
Protein NameDNA replication licensing factor MCM6
Human Gene Id4175
Human Swiss Prot NoQ14566
Mouse Gene Id17219
Mouse Swiss Prot NoP97311
Rat Swiss Prot NoQ62724
SpecificityMCM6 Polyclonal Antibody detects endogenous levels of MCM6 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMCM6; DNA replication licensing factor MCM6; p105MCM
Observed Band(KD)90
Functionfunction:May be involved in the control of a single round of DNA replication during S phase. Binds to chromatin during G1 and detach from it during S phase as if it licenses the chromatin to replicate.,polymorphism:Intronic variations in MCM6 upstream from the LCT gene are associated with adult-type hypolactasia [MIM:223100] leading to lactose intolerance, or with lactase persistance. Lactose intolerance is a normal physiological phenomenon caused by developmental down-regulation of lactase activity during childhood or early adulthood. A non-coding variation in MCM6 affects the transcriptional regulation of the LCT gene resulting in down-regulation of lactase activity. However the majority of Northern Europeans and some African populations have the ability to maintain lactase activity and digest lactose throughout life (lactase persistence).,PTM:Phosphorylated upon DNA damage, probably b
Subcellular LocationNucleus . Chromosome . Binds to chromatin during G1 and detach from it during S phase. .
ExpressionCervix,Epithelium,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human MCM6. AA range:331-380
Gene NameMCM6
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundminichromosome maintenance complex component 6(MCM6) Homo sapiens The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, i
Conjugated Antibody
This product is also available conjugated. Format: E20-75454-Conjugate. Price: $485 / Size: 100μl.
E20-75454-FITC$485 / 100μlE20-75454-Biotin$485 / 100μlE20-75454-HRP$485 / 100μlE20-75454-AP$485 / 100μlE20-75454-AF350$485 / 100μlE20-75454-AF405M$485 / 100μlE20-75454-AF488$485 / 100μlE20-75454-AF514$485 / 100μlE20-75454-AF532$485 / 100μlE20-75454-AF555$485 / 100μlE20-75454-AF568$485 / 100μlE20-75454-AF405S$485 / 100μlE20-75454-AF405L$485 / 100μlE20-75454-AF546$485 / 100μlE20-75454-AF594$485 / 100μlE20-75454-AF610$485 / 100μlE20-75454-AF635$485 / 100μlE20-75454-AF647$485 / 100μlE20-75454-AF680$485 / 100μlE20-75454-AF700$485 / 100μlE20-75454-AF750$485 / 100μlE20-75454-AF790$485 / 100μlE20-75454-APC$485 / 100μlE20-75454-PE$485 / 100μlE20-75454-Cy3$485 / 100μlE20-75454-Cy5$485 / 100μlE20-75454-Cy5.5$485 / 100μlE20-75454-Cy7$485 / 100μlE20-75454-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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