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Cell Signal Transduction Research Antibodies
SDHB Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight31630Da
Protein NameSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit mitochondrial
Human Gene Id6390
Human Swiss Prot NoP21912
Mouse Gene Id67680
Mouse Swiss Prot NoQ9CQA3
Rat Gene Id298596
Rat Swiss Prot NoP21913
SpecificitySDHB Polyclonal Antibody detects endogenous levels of SDHB protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSDHB; SDH; SDH1; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip
Observed Band(KD)31
Functioncatalytic activity:Succinate + ubiquinone = fumarate + ubiquinol.,cofactor:Binds 1 2Fe-2S cluster.,cofactor:Binds 1 3Fe-4S cluster.,cofactor:Binds 1 4Fe-4S cluster.,disease:Defects in SDHB are a cause of Cowden-like syndrome [MIM:612359]. Cowden-like syndrome is a cancer predisposition syndrome associated with elevated risk for tumors of the breast, thyroid, kidney and uterus.,disease:Defects in SDHB are a cause of paraganglioma and gastric stromal sarcoma [MIM:606864]; also called Carney-Stratakis syndrome. Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with inc
Subcellular LocationMitochondrion inner membrane; Peripheral membrane protein; Matrix side.
ExpressionBrain,Fibroblast,Liver,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SDHB. AA range:131-180
Gene NameSDHB
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsuccinate dehydrogenase complex iron sulfur subunit B(SDHB) Homo sapiens Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75450-Conjugate. Price: $485 / Size: 100μl.
E20-75450-FITC$485 / 100μlE20-75450-Biotin$485 / 100μlE20-75450-HRP$485 / 100μlE20-75450-AP$485 / 100μlE20-75450-AF350$485 / 100μlE20-75450-AF405M$485 / 100μlE20-75450-AF488$485 / 100μlE20-75450-AF514$485 / 100μlE20-75450-AF532$485 / 100μlE20-75450-AF555$485 / 100μlE20-75450-AF568$485 / 100μlE20-75450-AF405S$485 / 100μlE20-75450-AF405L$485 / 100μlE20-75450-AF546$485 / 100μlE20-75450-AF594$485 / 100μlE20-75450-AF610$485 / 100μlE20-75450-AF635$485 / 100μlE20-75450-AF647$485 / 100μlE20-75450-AF680$485 / 100μlE20-75450-AF700$485 / 100μlE20-75450-AF750$485 / 100μlE20-75450-AF790$485 / 100μlE20-75450-APC$485 / 100μlE20-75450-PE$485 / 100μlE20-75450-Cy3$485 / 100μlE20-75450-Cy5$485 / 100μlE20-75450-Cy5.5$485 / 100μlE20-75450-Cy7$485 / 100μlE20-75450-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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