World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
D3DR Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight44225Da
Protein NameD(3) dopamine receptor
Human Gene Id1814
Human Swiss Prot NoP35462
Mouse Gene Id13490
Mouse Swiss Prot NoP30728
Rat Gene Id29238
Rat Swiss Prot NoP19020
SpecificityD3DR Polyclonal Antibody detects endogenous levels of D3DR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDRD3; D(3) dopamine receptor; Dopamine D3 receptor
Observed Band(KD)44
Functiondisease:Genetic variation in DRD3 may be associated with susceptibility to hereditary essential tremor 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.,function:This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with CLIC6.,tissue specificity:Brain.,
Subcellular LocationCell membrane ; Multi-pass membrane protein . Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
ExpressionBrain.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from D3DR . at AA range: 181-230
Gene NameDRD3
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgrounddopamine receptor D3(DRD3) Homo sapiens This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75448-Conjugate. Price: $485 / Size: 100μl.
E20-75448-FITC$485 / 100μlE20-75448-Biotin$485 / 100μlE20-75448-HRP$485 / 100μlE20-75448-AP$485 / 100μlE20-75448-AF350$485 / 100μlE20-75448-AF405M$485 / 100μlE20-75448-AF488$485 / 100μlE20-75448-AF514$485 / 100μlE20-75448-AF532$485 / 100μlE20-75448-AF555$485 / 100μlE20-75448-AF568$485 / 100μlE20-75448-AF405S$485 / 100μlE20-75448-AF405L$485 / 100μlE20-75448-AF546$485 / 100μlE20-75448-AF594$485 / 100μlE20-75448-AF610$485 / 100μlE20-75448-AF635$485 / 100μlE20-75448-AF647$485 / 100μlE20-75448-AF680$485 / 100μlE20-75448-AF700$485 / 100μlE20-75448-AF750$485 / 100μlE20-75448-AF790$485 / 100μlE20-75448-APC$485 / 100μlE20-75448-PE$485 / 100μlE20-75448-Cy3$485 / 100μlE20-75448-Cy5$485 / 100μlE20-75448-Cy5.5$485 / 100μlE20-75448-Cy7$485 / 100μlE20-75448-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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