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Cell Signal Transduction Research Antibodies
FOXP3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight47410Da
Protein NameForkhead box protein P3
Human Gene Id50943
Human Swiss Prot NoQ9BZS1
Mouse Gene Id20371
Mouse Swiss Prot NoQ99JB6
SpecificityFOXP3 Polyclonal Antibody detects endogenous levels of FOXP3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin
Observed Band(KD)47
Functiondisease:Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.,function:Probable transcription factor. Plays a critical role in the control of immune response.,online information:FOXP3 entry,online information:FOXP3 mutation db,similarity:Contains 1 C2H2-type zinc finger.,similarity:Contains 1 fork-head DNA-binding domain.,
Subcellular LocationNucleus . Cytoplasm . Predominantly expressed in the cytoplasm in activated conventional T-cells whereas predominantly expressed in the nucleus in regulatory T-cells (Treg). The 41 kDa form derived by proteolytic processing is found exclusively in the chromatin fraction of activated Treg cells (By similarity). .
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human FOXP3. AA range:381-430
Gene NameFOXP3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundforkhead box P3(FOXP3) Homo sapiens The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75446-Conjugate. Price: $485 / Size: 100μl.
E20-75446-FITC$485 / 100μlE20-75446-Biotin$485 / 100μlE20-75446-HRP$485 / 100μlE20-75446-AP$485 / 100μlE20-75446-AF350$485 / 100μlE20-75446-AF405M$485 / 100μlE20-75446-AF488$485 / 100μlE20-75446-AF514$485 / 100μlE20-75446-AF532$485 / 100μlE20-75446-AF555$485 / 100μlE20-75446-AF568$485 / 100μlE20-75446-AF405S$485 / 100μlE20-75446-AF405L$485 / 100μlE20-75446-AF546$485 / 100μlE20-75446-AF594$485 / 100μlE20-75446-AF610$485 / 100μlE20-75446-AF635$485 / 100μlE20-75446-AF647$485 / 100μlE20-75446-AF680$485 / 100μlE20-75446-AF700$485 / 100μlE20-75446-AF750$485 / 100μlE20-75446-AF790$485 / 100μlE20-75446-APC$485 / 100μlE20-75446-PE$485 / 100μlE20-75446-Cy3$485 / 100μlE20-75446-Cy5$485 / 100μlE20-75446-Cy5.5$485 / 100μlE20-75446-Cy7$485 / 100μlE20-75446-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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