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Cell Signal Transduction Research Antibodies
MAPK Organizer 1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight34343Da
Protein NameWD repeat domain-containing protein 83
Human Gene Id84292
Human Swiss Prot NoQ9BRX9
Mouse Gene Id67836
Mouse Swiss Prot NoQ9DAJ4
Rat Gene Id288924
Rat Swiss Prot NoQ5BLX8
SpecificityMAPK Organizer 1 Polyclonal Antibody detects endogenous levels of MAPK Organizer 1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameWDR83; MORG1; WD repeat domain-containing protein 83; Mitogen-activated protein kinase organizer 1; MAPK organizer 1
Observed Band(KD)34
Functionfunction:Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.,similarity:Belongs to the WD repeat MORG1 family.,similarity:Contains 7 WD repeats.,subcellular location:Predominantly cytoplasmic (By similarity). Partially nuclear.,subunit:Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, MAP2K1IP1/M
Subcellular LocationCytoplasm . Nucleus . Predominantly cytoplasmic. Partially nuclear. .
ExpressionKidney proximal tubule,Muscle,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human WDR83. AA range:141-190
Gene NameWDR83
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundWD repeat domain 83(WDR83) Homo sapiens This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75445-Conjugate. Price: $485 / Size: 100μl.
E20-75445-FITC$485 / 100μlE20-75445-Biotin$485 / 100μlE20-75445-HRP$485 / 100μlE20-75445-AP$485 / 100μlE20-75445-AF350$485 / 100μlE20-75445-AF405M$485 / 100μlE20-75445-AF488$485 / 100μlE20-75445-AF514$485 / 100μlE20-75445-AF532$485 / 100μlE20-75445-AF555$485 / 100μlE20-75445-AF568$485 / 100μlE20-75445-AF405S$485 / 100μlE20-75445-AF405L$485 / 100μlE20-75445-AF546$485 / 100μlE20-75445-AF594$485 / 100μlE20-75445-AF610$485 / 100μlE20-75445-AF635$485 / 100μlE20-75445-AF647$485 / 100μlE20-75445-AF680$485 / 100μlE20-75445-AF700$485 / 100μlE20-75445-AF750$485 / 100μlE20-75445-AF790$485 / 100μlE20-75445-APC$485 / 100μlE20-75445-PE$485 / 100μlE20-75445-Cy3$485 / 100μlE20-75445-Cy5$485 / 100μlE20-75445-Cy5.5$485 / 100μlE20-75445-Cy7$485 / 100μlE20-75445-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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