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Cell Signal Transduction Research Antibodies
ApoA-I Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight31kDa
Protein NameApolipoprotein A-I
Human Gene Id335
Human Swiss Prot NoP02647
Mouse Gene Id11806
Mouse Swiss Prot NoQ00623
SpecificityApoA-I Polyclonal Antibody detects endogenous levels of ApoA-I protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameAPOA1; Apolipoprotein A-I; Apo-AI; ApoA-I; Apolipoprotein A1
Observed Band(KD)31
Functiondisease:Defects in APOA1 are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.,disease:Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2) [MIM:604091]; also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant.,disease:Defects in APOA1 are a cause of the low HDL levels observed in high density lipoprotein deficiency type 1 (HDLD1) [MIM:205400]; also known as analphalipoproteinemia or Tangier dis
Subcellular LocationSecreted.
ExpressionMajor protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human APOA1. AA range:81-130
Gene NameAPOA1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundapolipoprotein A1(APOA1) Homo sapiens This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75439-Conjugate. Price: $485 / Size: 100μl.
E20-75439-FITC$485 / 100μlE20-75439-Biotin$485 / 100μlE20-75439-HRP$485 / 100μlE20-75439-AP$485 / 100μlE20-75439-AF350$485 / 100μlE20-75439-AF405M$485 / 100μlE20-75439-AF488$485 / 100μlE20-75439-AF514$485 / 100μlE20-75439-AF532$485 / 100μlE20-75439-AF555$485 / 100μlE20-75439-AF568$485 / 100μlE20-75439-AF405S$485 / 100μlE20-75439-AF405L$485 / 100μlE20-75439-AF546$485 / 100μlE20-75439-AF594$485 / 100μlE20-75439-AF610$485 / 100μlE20-75439-AF635$485 / 100μlE20-75439-AF647$485 / 100μlE20-75439-AF680$485 / 100μlE20-75439-AF700$485 / 100μlE20-75439-AF750$485 / 100μlE20-75439-AF790$485 / 100μlE20-75439-APC$485 / 100μlE20-75439-PE$485 / 100μlE20-75439-Cy3$485 / 100μlE20-75439-Cy5$485 / 100μlE20-75439-Cy5.5$485 / 100μlE20-75439-Cy7$485 / 100μlE20-75439-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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