Tubulin α Polyclonal Antibody

Name: Tubulin α Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75431
Price: 225 USD
Availability: InStock

E20-75431Cite ID: EN0055564Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight50136/50152/49895Da

Protein NameTubulin alpha-1A chain/Tubulin alpha-1B chain/Tubulin alpha-1C chain

Human Gene Id7846/10376/84790

Human Swiss Prot NoQ71U36/P68363/Q9BQE3

Mouse Gene Id22142/22143/22146

Rat Gene Id64158/500929/100909441

Rat Swiss Prot NoP68370/Q6P9V9/Q6AYZ1

SpecificityTubulin α Polyclonal Antibody detects endogenous levels of Tubulin α protein only when acetylation at K112.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameTUBA1A; TUBA3; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain; TUBA1B; Tubulin alpha-1B chain; Alpha-tubulin ubiquitousTubulin K-alpha-1; Tubulin alpha-ubiquitous chain; TUBA1C; TUBA6; Tubulin alpha-1C chain; Alpha-tubulin 6; Tubulin alpha-6 chain

Observed Band(KD)50

Functiondisease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), resp

Subcellular LocationCytoplasm, cytoskeleton.

ExpressionExpressed at a high level in fetal brain.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from human Tubulin α around the non-acetylation site of K112.

Gene NameTUBA1A/TUBA1B/TUBA1C

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundtubulin alpha 1a(TUBA1A) Homo sapiens Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75431-Conjugate. Price: $485 / Size: 100μl.

E20-75431-FITC$485 / 100μlE20-75431-Biotin$485 / 100μlE20-75431-HRP$485 / 100μlE20-75431-AP$485 / 100μlE20-75431-AF350$485 / 100μlE20-75431-AF405M$485 / 100μlE20-75431-AF488$485 / 100μlE20-75431-AF514$485 / 100μlE20-75431-AF532$485 / 100μlE20-75431-AF555$485 / 100μlE20-75431-AF568$485 / 100μlE20-75431-AF405S$485 / 100μlE20-75431-AF405L$485 / 100μlE20-75431-AF546$485 / 100μlE20-75431-AF594$485 / 100μlE20-75431-AF610$485 / 100μlE20-75431-AF635$485 / 100μlE20-75431-AF647$485 / 100μlE20-75431-AF680$485 / 100μlE20-75431-AF700$485 / 100μlE20-75431-AF750$485 / 100μlE20-75431-AF790$485 / 100μlE20-75431-APC$485 / 100μlE20-75431-PE$485 / 100μlE20-75431-Cy3$485 / 100μlE20-75431-Cy5$485 / 100μlE20-75431-Cy5.5$485 / 100μlE20-75431-Cy7$485 / 100μlE20-75431-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.