World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
PCAF Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight93013Da
Protein NameHistone acetyltransferase KAT2B
Human Gene Id8850
Human Swiss Prot NoQ92831
Mouse Gene Id18519
Mouse Swiss Prot NoQ9JHD1
SpecificityPCAF Polyclonal Antibody detects endogenous levels of PCAF protein only when acetylation at K428.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKAT2B; PCAF; Histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF
Observed Band(KD)93
Functionchromatin organization, chromatin remodeling, transcription, regulation of transcription, DNA-dependent, protein amino acid acetylation, N-terminal protein amino acid acetylation, cell cycle, cell cycle arrest, negative regulation of cell proliferation, response to endogenous stimulus, response to hormone stimulus, response to organic substance,chromatin modification, covalent chromatin modification, histone modification, histone acetylation, N-terminal peptidyl-lysine acetylation, peptidyl-lysine modification, peptidyl-lysine acetylation, cell cycle process, N-terminal protein amino acid modification, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, regulation of cell proliferation, response to peptide hormone stimulus, protein amino acid acylation,regulation of transcription, regulation of RNA metabolic process, chromosome orga
Subcellular LocationNucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255). .
ExpressionUbiquitously expressed but most abundant in heart and skeletal muscle. Also expressed in the skin, in keratinocytes (at protein level) (PubMed:20940255).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from human PCAF around the non-acetylation site of K428.
Gene NameKAT2B
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundlysine acetyltransferase 2B(KAT2B) Homo sapiens CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75429-Conjugate. Price: $485 / Size: 100μl.
E20-75429-FITC$485 / 100μlE20-75429-Biotin$485 / 100μlE20-75429-HRP$485 / 100μlE20-75429-AP$485 / 100μlE20-75429-AF350$485 / 100μlE20-75429-AF405M$485 / 100μlE20-75429-AF488$485 / 100μlE20-75429-AF514$485 / 100μlE20-75429-AF532$485 / 100μlE20-75429-AF555$485 / 100μlE20-75429-AF568$485 / 100μlE20-75429-AF405S$485 / 100μlE20-75429-AF405L$485 / 100μlE20-75429-AF546$485 / 100μlE20-75429-AF594$485 / 100μlE20-75429-AF610$485 / 100μlE20-75429-AF635$485 / 100μlE20-75429-AF647$485 / 100μlE20-75429-AF680$485 / 100μlE20-75429-AF700$485 / 100μlE20-75429-AF750$485 / 100μlE20-75429-AF790$485 / 100μlE20-75429-APC$485 / 100μlE20-75429-PE$485 / 100μlE20-75429-Cy3$485 / 100μlE20-75429-Cy5$485 / 100μlE20-75429-Cy5.5$485 / 100μlE20-75429-Cy7$485 / 100μlE20-75429-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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