World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
HSP70 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight70052Da
Protein NameHeat shock 70 kDa protein 1A/1B
Human Gene Id3303/3304
Human Swiss Prot NoP08107
SpecificityHSP70 Polyclonal Antibody detects endogenous levels of HSP70 protein only when acetylation at K246.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameHSPA1A; HSPA1; HSPA1B; Heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1/2; HSP70-1/HSP70-2; HSP70.1/HSP70.2
Observed Band(KD)70
Functionfunction:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.,induction:By heat shock.,similarity:Belongs to the heat shock protein 70 family.,subunit:HSPA1B is found in a sperm-specific complex with CATSPER1 and CATSPERB (By similarity). Interacts with TSC2. Interacts with IRAK1BP1.,tissue specificity:HSPA1B is testis-specific
Subcellular Locationubiquitin ligase complex,nucleoplasm,cytoplasm,mitochondrion,centriole,cytosol,cell-cell adherens junction,focal adhesion,inclusion body,perinuclear region of cytoplasm,blood microparticle,
ExpressionBrain,Cajal-Retzius cell,Embryonic kidney,Epithelium,Fetal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from human HSP70 around the non-acetylation site of K246.
Gene NameHSPA1A
DilutionIF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundheat shock protein family A (Hsp70) member 1A(HSPA1A) Homo sapiens This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75424-Conjugate. Price: $485 / Size: 100μl.
E20-75424-FITC$485 / 100μlE20-75424-Biotin$485 / 100μlE20-75424-HRP$485 / 100μlE20-75424-AP$485 / 100μlE20-75424-AF350$485 / 100μlE20-75424-AF405M$485 / 100μlE20-75424-AF488$485 / 100μlE20-75424-AF514$485 / 100μlE20-75424-AF532$485 / 100μlE20-75424-AF555$485 / 100μlE20-75424-AF568$485 / 100μlE20-75424-AF405S$485 / 100μlE20-75424-AF405L$485 / 100μlE20-75424-AF546$485 / 100μlE20-75424-AF594$485 / 100μlE20-75424-AF610$485 / 100μlE20-75424-AF635$485 / 100μlE20-75424-AF647$485 / 100μlE20-75424-AF680$485 / 100μlE20-75424-AF700$485 / 100μlE20-75424-AF750$485 / 100μlE20-75424-AF790$485 / 100μlE20-75424-APC$485 / 100μlE20-75424-PE$485 / 100μlE20-75424-Cy3$485 / 100μlE20-75424-Cy5$485 / 100μlE20-75424-Cy5.5$485 / 100μlE20-75424-Cy7$485 / 100μlE20-75424-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits