World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
BMAL1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight68762Da
Protein NameAryl hydrocarbon receptor nuclear translocator-like protein 1
Human Gene Id406
Human Swiss Prot NoO00327
Mouse Gene Id11865
Mouse Swiss Prot NoQ9WTL8
Rat Gene Id29657
Rat Swiss Prot NoQ9EPW1
SpecificityBMAL1 Polyclonal Antibody detects endogenous levels of BMAL1 protein only when acetylation at K538.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameARNTL; BHLHE5; BMAL1; MOP3; PASD3; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1Class E basic helix-loop-helix protein 5; bHLHe5; Member of PAS protein 3; PAS domain-containing protein 3; bHLH-PAS protein JAP3
Observed Band(KD)69
Functionalternative products:Additional isoforms seem to exist,function:ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,miscellaneous:CLOCK-ARNTL double mutations within the PAS domains result in syngernistic desensitization to high levels of CRY on repression of CLOCK-ARNTL transcriptional activity of PER1 and, disrupt circadian rhythmicity.,PTM:Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression.,PTM:Phosphorylated upon dimerization with CLOCK.,PTM:Sumoylated on Lys-259 upon dimerization with CLOCK.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component
Subcellular Locationnucleus,nucleoplasm,transcription factor complex,cytoplasm,PML body,chromatoid body,intracellular membrane-bounded organelle,
ExpressionBrain,Fetal brain,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human BMAL1 around the non-acetylation site of Lys538. AA range:501-550
Gene NameARNTL
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundaryl hydrocarbon receptor nuclear translocator like(ARNTL) Homo sapiens The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75423-Conjugate. Price: $485 / Size: 100μl.
E20-75423-FITC$485 / 100μlE20-75423-Biotin$485 / 100μlE20-75423-HRP$485 / 100μlE20-75423-AP$485 / 100μlE20-75423-AF350$485 / 100μlE20-75423-AF405M$485 / 100μlE20-75423-AF488$485 / 100μlE20-75423-AF514$485 / 100μlE20-75423-AF532$485 / 100μlE20-75423-AF555$485 / 100μlE20-75423-AF568$485 / 100μlE20-75423-AF405S$485 / 100μlE20-75423-AF405L$485 / 100μlE20-75423-AF546$485 / 100μlE20-75423-AF594$485 / 100μlE20-75423-AF610$485 / 100μlE20-75423-AF635$485 / 100μlE20-75423-AF647$485 / 100μlE20-75423-AF680$485 / 100μlE20-75423-AF700$485 / 100μlE20-75423-AF750$485 / 100μlE20-75423-AF790$485 / 100μlE20-75423-APC$485 / 100μlE20-75423-PE$485 / 100μlE20-75423-Cy3$485 / 100μlE20-75423-Cy5$485 / 100μlE20-75423-Cy5.5$485 / 100μlE20-75423-Cy7$485 / 100μlE20-75423-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits