World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
IDH1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight46659Da
Protein NameIsocitrate dehydrogenase [NADP] cytoplasmic
Human Gene Id3417
Human Swiss Prot NoO75874
Mouse Gene Id15926
Mouse Swiss Prot NoO88844
Rat Gene Id24479
Rat Swiss Prot NoP41562
SpecificityIDH1 Polyclonal Antibody detects endogenous levels of IDH1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIDH1; PICD; Isocitrate dehydrogenase [NADP] cytoplasmic; IDH; Cytosolic NADP-isocitrate dehydrogenase; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase
Observed Band(KD)46
Functioncatalytic activity:Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.,catalytic activity:Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.,cofactor:Binds 1 magnesium or manganese ion per subunit.,disease:Defects in IDH1 are a cause of glioblastoma multiforme (GBM) [MIM:137800]; also called familial glioma of brain. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas.,miscellaneous:Cancer mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas.,online information:Isocitrate dehydrogenase entry,similarity:Belongs to the isocitrate and isopropylmalate dehydrogenases family.,subunit:Homodimer.,
Subcellular Locationcytoplasm,mitochondrion,peroxisome,peroxisomal matrix,cytosol,cell-cell adherens junction,extracellular exosome,
ExpressionBrain,Cajal-Retzius cell,Fetal brain cortex,Human endometri
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the N-terminal region of human IDH1.
Gene NameIDH1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundisocitrate dehydrogenase (NADP(+)) 1, cytosolic(IDH1) Homo sapiens Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to
Conjugated Antibody
This product is also available conjugated. Format: E20-75416-Conjugate. Price: $485 / Size: 100μl.
E20-75416-FITC$485 / 100μlE20-75416-Biotin$485 / 100μlE20-75416-HRP$485 / 100μlE20-75416-AP$485 / 100μlE20-75416-AF350$485 / 100μlE20-75416-AF405M$485 / 100μlE20-75416-AF488$485 / 100μlE20-75416-AF514$485 / 100μlE20-75416-AF532$485 / 100μlE20-75416-AF555$485 / 100μlE20-75416-AF568$485 / 100μlE20-75416-AF405S$485 / 100μlE20-75416-AF405L$485 / 100μlE20-75416-AF546$485 / 100μlE20-75416-AF594$485 / 100μlE20-75416-AF610$485 / 100μlE20-75416-AF635$485 / 100μlE20-75416-AF647$485 / 100μlE20-75416-AF680$485 / 100μlE20-75416-AF700$485 / 100μlE20-75416-AF750$485 / 100μlE20-75416-AF790$485 / 100μlE20-75416-APC$485 / 100μlE20-75416-PE$485 / 100μlE20-75416-Cy3$485 / 100μlE20-75416-Cy5$485 / 100μlE20-75416-Cy5.5$485 / 100μlE20-75416-Cy7$485 / 100μlE20-75416-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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