World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
TPO Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37823Da
Protein NameThrombopoietin
Human Gene Id7066
Human Swiss Prot NoP40225
Mouse Gene Id21832
Mouse Swiss Prot NoP40226
Rat Gene Id81811
Rat Swiss Prot NoP49745
SpecificityTPO Polyclonal Antibody detects endogenous levels of TPO protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTHPO; MGDF; Thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
Observed Band(KD)38
Functiondisease:Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.,domain:Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.,function:Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.,similarity:Belongs to the EPO/TPO family.,
Subcellular Locationextracellular region,extracellular space,
ExpressionBrain,Fetal liver,Liver,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human THPO. AA range:41-90
Gene NameTHPO
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundthrombopoietin(THPO) Homo sapiens Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent. [provided by RefSeq, Feb 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75413-Conjugate. Price: $485 / Size: 100μl.
E20-75413-FITC$485 / 100μlE20-75413-Biotin$485 / 100μlE20-75413-HRP$485 / 100μlE20-75413-AP$485 / 100μlE20-75413-AF350$485 / 100μlE20-75413-AF405M$485 / 100μlE20-75413-AF488$485 / 100μlE20-75413-AF514$485 / 100μlE20-75413-AF532$485 / 100μlE20-75413-AF555$485 / 100μlE20-75413-AF568$485 / 100μlE20-75413-AF405S$485 / 100μlE20-75413-AF405L$485 / 100μlE20-75413-AF546$485 / 100μlE20-75413-AF594$485 / 100μlE20-75413-AF610$485 / 100μlE20-75413-AF635$485 / 100μlE20-75413-AF647$485 / 100μlE20-75413-AF680$485 / 100μlE20-75413-AF700$485 / 100μlE20-75413-AF750$485 / 100μlE20-75413-AF790$485 / 100μlE20-75413-APC$485 / 100μlE20-75413-PE$485 / 100μlE20-75413-Cy3$485 / 100μlE20-75413-Cy5$485 / 100μlE20-75413-Cy5.5$485 / 100μlE20-75413-Cy7$485 / 100μlE20-75413-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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