Product Information
Molecular Weight47442Da
Protein NameInhibin beta A chain
Human Gene Id3624
Human Swiss Prot NoP08476
Mouse Gene Id16323
Mouse Swiss Prot NoQ04998
Rat Gene Id29200
Rat Swiss Prot NoP18331
SpecificityInhibin β-A Polyclonal Antibody detects endogenous levels of Inhibin β-A protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameINHBA; Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein; EDF
Observed Band(KD)52
FunctionInhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.,online information:Activin entry,similarity:Belongs to the TGF-beta family.,subunit:Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B. Activin A is a homodimer of beta-A. Activin B is a homodimer of beta-B. Activin AB is a dimer of beta-A and beta-B.,
Subcellular Locationextracellular region,activin A complex,inhibin A complex,perinuclear region of cytoplasm,
ExpressionDermoid cancer,Eye,Fetal brain,Testis,
Backgroundinhibin beta A subunit(INHBA) Homo sapiens This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016],