World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
RANKL Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight35478Da
Protein NameTumor necrosis factor ligand superfamily member 11
Human Gene Id8600
Human Swiss Prot NoO14788
Mouse Gene Id21943
Mouse Swiss Prot NoO35235
Rat Gene Id117516
Rat Swiss Prot NoQ9ESE2
SpecificityRANKL Polyclonal Antibody detects endogenous levels of RANKL protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNFSF11; OPGL; RANKL; TRANCE; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGLReceptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD254
Observed Band(KD)35
Functiondisease:Defects in TNFSF11 are the cause of osteopetrosis autosomal recessive type 2 (OPTB2) [MIM:259710]; also known as osteoclast-poor osteopetrosis. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB2 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development.,function:Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an
Subcellular Locationextracellular region,extracellular space,intracellular,cytoplasm,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,
ExpressionBone marrow,Brain,Lung,Lymph node,Peripheral blood,Thymocyt
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human TNFSF11. AA range:268-317
Gene NameTNFSF11
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundtumor necrosis factor superfamily member 11(TNFSF11) Homo sapiens This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B ly
Conjugated Antibody
This product is also available conjugated. Format: E20-75404-Conjugate. Price: $485 / Size: 100μl.
E20-75404-FITC$485 / 100μlE20-75404-Biotin$485 / 100μlE20-75404-HRP$485 / 100μlE20-75404-AP$485 / 100μlE20-75404-AF350$485 / 100μlE20-75404-AF405M$485 / 100μlE20-75404-AF488$485 / 100μlE20-75404-AF514$485 / 100μlE20-75404-AF532$485 / 100μlE20-75404-AF555$485 / 100μlE20-75404-AF568$485 / 100μlE20-75404-AF405S$485 / 100μlE20-75404-AF405L$485 / 100μlE20-75404-AF546$485 / 100μlE20-75404-AF594$485 / 100μlE20-75404-AF610$485 / 100μlE20-75404-AF635$485 / 100μlE20-75404-AF647$485 / 100μlE20-75404-AF680$485 / 100μlE20-75404-AF700$485 / 100μlE20-75404-AF750$485 / 100μlE20-75404-AF790$485 / 100μlE20-75404-APC$485 / 100μlE20-75404-PE$485 / 100μlE20-75404-Cy3$485 / 100μlE20-75404-Cy5$485 / 100μlE20-75404-Cy5.5$485 / 100μlE20-75404-Cy7$485 / 100μlE20-75404-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits