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Cell Signal Transduction Research Antibodies
Endo180 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight166655Da
Protein NameC-type mannose receptor 2
Human Gene Id9902
Human Swiss Prot NoQ9UBG0
Mouse Gene Id17534
Mouse Swiss Prot NoQ64449
Rat Gene Id498011
Rat Swiss Prot NoQ4TU93
SpecificityEndo180 Polyclonal Antibody detects endogenous levels of Endo180 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMRC2; CLEC13E; ENDO180; KIAA0709; UPARAP; C-type mannose receptor 2; C-type lectin domain family 13 member E; Endocytic receptor 180; Macrophage mannose receptor 2Urokinase-type plasminogen activator receptor-associated protein; UPAR-associated protein; Urokinase receptor-associated protein; CD280
Observed Band(KD)170
Functiondomain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,domain:Fibronectin type-II domain mediates collagen-binding.,domain:Ricin B-type lectin domain contacts with the second C-type lectin domain.,function:May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as
Subcellular Locationintegral component of plasma membrane,focal adhesion,membrane,integral component of membrane,
ExpressionBrain,Liver,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human MRC2. AA range:721-770
Gene NameMRC2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmannose receptor C type 2(MRC2) Homo sapiens This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-75403-Conjugate. Price: $485 / Size: 100μl.
E20-75403-FITC$485 / 100μlE20-75403-Biotin$485 / 100μlE20-75403-HRP$485 / 100μlE20-75403-AP$485 / 100μlE20-75403-AF350$485 / 100μlE20-75403-AF405M$485 / 100μlE20-75403-AF488$485 / 100μlE20-75403-AF514$485 / 100μlE20-75403-AF532$485 / 100μlE20-75403-AF555$485 / 100μlE20-75403-AF568$485 / 100μlE20-75403-AF405S$485 / 100μlE20-75403-AF405L$485 / 100μlE20-75403-AF546$485 / 100μlE20-75403-AF594$485 / 100μlE20-75403-AF610$485 / 100μlE20-75403-AF635$485 / 100μlE20-75403-AF647$485 / 100μlE20-75403-AF680$485 / 100μlE20-75403-AF700$485 / 100μlE20-75403-AF750$485 / 100μlE20-75403-AF790$485 / 100μlE20-75403-APC$485 / 100μlE20-75403-PE$485 / 100μlE20-75403-Cy3$485 / 100μlE20-75403-Cy5$485 / 100μlE20-75403-Cy5.5$485 / 100μlE20-75403-Cy7$485 / 100μlE20-75403-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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