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Cell Signal Transduction Research Antibodies
Jagged1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight):133799Da
Protein NameProtein jagged-1
Human Gene Id182
Human Swiss Prot NoP78504
Mouse Gene Id16449
Mouse Swiss Prot NoQ9QXX0
Rat Gene Id29146
Rat Swiss Prot NoQ63722
SpecificityJagged1 Polyclonal Antibody detects endogenous levels of Jagged1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameJAG1; JAGL1; Protein jagged-1; Jagged1; hJ1; CD339
Observed Band(KD)140
Functiondevelopmental stage:Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otocyst, branchial arches, metanephros, pancreas, mesocardium, around the major bronchial branches, and in the neural tube.,disease:Defects in JAG1 are a cause of tetralogy of Fallot (TOF) [MIM:187500]. TOF is a congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. This condition results in a blue baby at birth due to inadequate oxygenation. Surgical correction is emergent.,disease:Defects in JAG1 are the cause of Alagille syndrome type 1 (ALGS1) [MIM:118450]. Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis
Subcellular LocationMembrane; Single-pass type I membrane protein.
ExpressionWidely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human JAG1. AA range:981-1030
Gene NameJAG1
DilutionIF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundjagged 1(JAG1) Homo sapiens The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75401-Conjugate. Price: $485 / Size: 100μl.
E20-75401-FITC$485 / 100μlE20-75401-Biotin$485 / 100μlE20-75401-HRP$485 / 100μlE20-75401-AP$485 / 100μlE20-75401-AF350$485 / 100μlE20-75401-AF405M$485 / 100μlE20-75401-AF488$485 / 100μlE20-75401-AF514$485 / 100μlE20-75401-AF532$485 / 100μlE20-75401-AF555$485 / 100μlE20-75401-AF568$485 / 100μlE20-75401-AF405S$485 / 100μlE20-75401-AF405L$485 / 100μlE20-75401-AF546$485 / 100μlE20-75401-AF594$485 / 100μlE20-75401-AF610$485 / 100μlE20-75401-AF635$485 / 100μlE20-75401-AF647$485 / 100μlE20-75401-AF680$485 / 100μlE20-75401-AF700$485 / 100μlE20-75401-AF750$485 / 100μlE20-75401-AF790$485 / 100μlE20-75401-APC$485 / 100μlE20-75401-PE$485 / 100μlE20-75401-Cy3$485 / 100μlE20-75401-Cy5$485 / 100μlE20-75401-Cy5.5$485 / 100μlE20-75401-Cy7$485 / 100μlE20-75401-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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