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Cell Signal Transduction Research Antibodies
CD148 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight145941Da
Protein NameReceptor-type tyrosine-protein phosphatase eta
Human Gene Id5795
Human Swiss Prot NoQ12913
Mouse Gene Id19271
Mouse Swiss Prot NoQ64455
SpecificityCD148 Polyclonal Antibody detects endogenous levels of CD148 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePTPRJ; DEP1; Receptor-type tyrosine-protein phosphatase eta; Protein-tyrosine phosphatase eta; R-PTP-eta; Density-enhanced phosphatase 1; DEP-1; HPTP eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; CD148
Observed Band(KD)150
Functioncatalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in PTPRJ are found in cancers of colon, lung, and breast.,function:May contribute to the mechanism of contact inhibition of cell growth.,PTM:N- and O-glycosylated.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 9 fibronectin type-III domains.,
Subcellular LocationCell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane . Cell junction. After T-cell stimulation, it is temporarily excluded from immunological synapses.
ExpressionExpressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PTPRJ. AA range:861-910
Gene NamePTPRJ
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundprotein tyrosine phosphatase, receptor type J(PTPRJ) Homo sapiens The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms
Conjugated Antibody
This product is also available conjugated. Format: E20-75400-Conjugate. Price: $485 / Size: 100μl.
E20-75400-FITC$485 / 100μlE20-75400-Biotin$485 / 100μlE20-75400-HRP$485 / 100μlE20-75400-AP$485 / 100μlE20-75400-AF350$485 / 100μlE20-75400-AF405M$485 / 100μlE20-75400-AF488$485 / 100μlE20-75400-AF514$485 / 100μlE20-75400-AF532$485 / 100μlE20-75400-AF555$485 / 100μlE20-75400-AF568$485 / 100μlE20-75400-AF405S$485 / 100μlE20-75400-AF405L$485 / 100μlE20-75400-AF546$485 / 100μlE20-75400-AF594$485 / 100μlE20-75400-AF610$485 / 100μlE20-75400-AF635$485 / 100μlE20-75400-AF647$485 / 100μlE20-75400-AF680$485 / 100μlE20-75400-AF700$485 / 100μlE20-75400-AF750$485 / 100μlE20-75400-AF790$485 / 100μlE20-75400-APC$485 / 100μlE20-75400-PE$485 / 100μlE20-75400-Cy3$485 / 100μlE20-75400-Cy5$485 / 100μlE20-75400-Cy5.5$485 / 100μlE20-75400-Cy7$485 / 100μlE20-75400-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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