World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
CD169 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight182624Da
Protein NameSialoadhesin
Human Gene Id6614
Human Swiss Prot NoQ9BZZ2
Mouse Gene Id20612
Mouse Swiss Prot NoQ62230
SpecificityCD169 Polyclonal Antibody detects endogenous levels of CD169 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSIGLEC1; SN; Sialoadhesin; Sialic acid-binding Ig-like lectin 1; Siglec-1; CD169
Observed Band(KD)190
Functionalternative products:Additional isoforms seem to exist,function:Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.,online information:Siglec-1,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 16 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. A
Subcellular Location[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
ExpressionExpressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophages in rheumatoid arthritis.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC1. AA range:1321-1370
Gene NameSIGLEC1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundsialic acid binding Ig like lectin 1(SIGLEC1) Homo sapiens This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75399-Conjugate. Price: $485 / Size: 100μl.
E20-75399-FITC$485 / 100μlE20-75399-Biotin$485 / 100μlE20-75399-HRP$485 / 100μlE20-75399-AP$485 / 100μlE20-75399-AF350$485 / 100μlE20-75399-AF405M$485 / 100μlE20-75399-AF488$485 / 100μlE20-75399-AF514$485 / 100μlE20-75399-AF532$485 / 100μlE20-75399-AF555$485 / 100μlE20-75399-AF568$485 / 100μlE20-75399-AF405S$485 / 100μlE20-75399-AF405L$485 / 100μlE20-75399-AF546$485 / 100μlE20-75399-AF594$485 / 100μlE20-75399-AF610$485 / 100μlE20-75399-AF635$485 / 100μlE20-75399-AF647$485 / 100μlE20-75399-AF680$485 / 100μlE20-75399-AF700$485 / 100μlE20-75399-AF750$485 / 100μlE20-75399-AF790$485 / 100μlE20-75399-APC$485 / 100μlE20-75399-PE$485 / 100μlE20-75399-Cy3$485 / 100μlE20-75399-Cy5$485 / 100μlE20-75399-Cy5.5$485 / 100μlE20-75399-Cy7$485 / 100μlE20-75399-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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