CD166 Polyclonal Antibody

Name: CD166 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75396
Price: 225 USD
Availability: InStock

E20-75396Cite ID: EN0055529Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight65102Da

Protein NameCD166 antigen

Human Gene Id214

Human Swiss Prot NoQ13740

Mouse Gene Id11658

Mouse Swiss Prot NoQ61490

Rat Gene Id79559

Rat Swiss Prot NoO35112

SpecificityCD166 Polyclonal Antibody detects endogenous levels of CD166 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameALCAM; MEMD; CD166 antigen; Activated leukocyte cell adhesion molecule; CD166

Observed Band(KD)65

Functiondomain:The CD6 binding site is located in the N-terminal Ig-like domain.,function:Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.,

Subcellular LocationCell membrane ; Single-pass type I membrane protein . Cell projection, axon . Cell projection, dendrite . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). .; [Isoform 3]: Secreted .

ExpressionDetected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human ALCAM. AA range:481-530

Gene NameALCAM

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundactivated leukocyte cell adhesion molecule(ALCAM) Homo sapiens This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75396-Conjugate. Price: $485 / Size: 100μl.

E20-75396-FITC$485 / 100μlE20-75396-Biotin$485 / 100μlE20-75396-HRP$485 / 100μlE20-75396-AP$485 / 100μlE20-75396-AF350$485 / 100μlE20-75396-AF405M$485 / 100μlE20-75396-AF488$485 / 100μlE20-75396-AF514$485 / 100μlE20-75396-AF532$485 / 100μlE20-75396-AF555$485 / 100μlE20-75396-AF568$485 / 100μlE20-75396-AF405S$485 / 100μlE20-75396-AF405L$485 / 100μlE20-75396-AF546$485 / 100μlE20-75396-AF594$485 / 100μlE20-75396-AF610$485 / 100μlE20-75396-AF635$485 / 100μlE20-75396-AF647$485 / 100μlE20-75396-AF680$485 / 100μlE20-75396-AF700$485 / 100μlE20-75396-AF750$485 / 100μlE20-75396-AF790$485 / 100μlE20-75396-APC$485 / 100μlE20-75396-PE$485 / 100μlE20-75396-Cy3$485 / 100μlE20-75396-Cy5$485 / 100μlE20-75396-Cy5.5$485 / 100μlE20-75396-Cy7$485 / 100μlE20-75396-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.